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ProteomicsSlight deuterium enrichment in water acts as an antioxidant: is deuterium a cell growth regulator?
Small admixtures in water, e.g. of metal ions, often act as cell growth regulators. Here we report that enrichment of deuterium content in water, normally found at 8 mM concentration, two-three folds increases cell proliferation and lowers the oxidative stress level as well. Acting as an anti-oxidan...
ORGANISM(S): Homo sapiens (Human) 
2020-08-10 | PXD018216 | Pride
Cell growth regulator Antioxidant Deuterium-enriched water Oxidantion-reduction balance 
TranscriptomicsEffect of deuterium oxide on Arabidopsis gene expression
2H2O has a long history as a protein or amino acid labeling techinique, and such labeling systems have proven effective for many different types of studies. A disadvantage of a 2H2O labeling system is that plant growth is inhibited as the percentage of deuterium in the medium increases. However the ...
ORGANISM(S): Arabidopsis thaliana 
2009-09-18 | GSE18153 | GEO
TranscriptomicsTranscription profiling of Arabidopsis after deuterium oxide treatment
2H2O has a long history as a protein or amino acid labeling techinique, and such labeling systems have proven effective for many different types of studies. A disadvantage of a 2H2O labeling system is that plant growth is inhibited as the percentage of deuterium in the medium increases. However the ...
ORGANISM(S): Arabidopsis thaliana 
2009-09-25 | E-GEOD-18153 | biostudies-arrayexpress
ProteomicsAnticancer effect of deuterium depleted water - comprehensive proteomics analysis suggests a redox disbalance mechanism
The proteomics data is derived from 4 parts of samples prepared and analysed by nanoLC-MS/MS. In order to make appropriate statistical analysed could be performed, all treatments were performed in biological replicates. The number of replicates was 4 for protein abundances analysis (part 1), 2 for t...
ORGANISM(S): Homo sapiens (Human) 
2019-09-26 | PXD011085 | Pride
Anticancer Proteomics Redox disbalance Deuterium depleted water 
ProteomicsDeuterium-free, Three-plexed Peptide Di-Ethylation for Highly Accurate Quantitative Proteomics
The deuterium, frequently used stable isotope in isotopic labeling for quantitative proteomics, could deteriorate the accuracy and precision of proteome quantification owing to the retention time shift of deuterated peptides from the hydrogenated counterpart. Herein, we introduce a novel three-plexe...
ORGANISM(S): Homo sapiens (Human) 
2019-01-17 | PXD012117 | Pride
Isobaric labeling Quantitative accuracy Di-methylation Isotopic labeling Deuterium effect Di-ethylation 
Genomics
Deuterium-Depleted Water environment adjusts the transcriptome and metabolome to alleviate cadmium toxicity in Saccharomyces cerevisiae
PRJNA1067743 | ENA
UnknownAnticancer Effect of Deuterium Depleted Water - Redox Disbalance Leads to Oxidative Stress.
Not available
S-EPMC6885702 | biostudies-literature
UnknownSlight Deuterium Enrichment in Water Acts as an Antioxidant: Is Deuterium a Cell Growth Regulator?
Not available
S-EPMC7664117 | biostudies-literature
ProteomicsAchieving a 35plex Tandem Mass Tag Reagent Set Through Deuterium Incorporation
Mass spectrometry-based sample multiplexing with isobaric tags permits the development of high-throughput and precise quantitative biological assays with proteome-wide coverage and minimal missing values. Here, we nearly double the multiplexing capability of the TMTpro reagent set to 35-plex through...
ORGANISM(S): Homo sapiens (Human) 
2024-10-17 | PXD054559 | Pride
Abpp Deuterium Isobaric tagging Tmtprod Tmtpro 
ProteomicsEukaryotic Ribosome GCN2 interaction Hydrogen/Deuterium Exchange Mass Spectrometry
General control nonderepressible 2 (GCN2) phosphorylates eIF2α, regulating translation in response to nutritional stress. Here, we show that mammalian ribosomes are potent GCN2 activators. Hydrogen/deuterium exchange–mass spectrometry (HDX-MS) showed GCN2 interacting with domain II of the uL10 P-sta...
ORGANISM(S): Oryctolagus cuniculus (Rabbit) 
2019-05-24 | PXD013051 | Pride
Ribosome Gcn2 Hdx-ms 
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