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ProteomicsTwo of a kind: Transmissible Schwann cell cancers in the endangered Tasmanian devil.
Devil facial tumour disease 1 and 2 (DFT1 and DFT2) are two genetically distinct transmissible cancers endangering the survival of the Tasmanian devil (Sarcophilus harrisii). DFT1 first arose from a cell of the Schwann cell lineage, however, the tissue-of-origin of the recently discovered DFT2 cance...
ORGANISM(S): Sarcophilus harrisii 
2019-08-06 | PXD011209 | Pride
Tasmanian devil Swath Devil facial tumour disease Proteomics 
ProteomicsProteomic analysis of Tasmanian devil facial tumour disease
The Tasmanian devil is the only mammalian species harbouring two lineages of contagious cancer within its population. This dataset represents the proteomics analysis of DFT1, DFT2 and SALEM lines.
ORGANISM(S): Sarcophilus harrisii 
2021-09-09 | PXD021784 | Pride
Dft2 Contagious cancer Devil facial tumour 1 Devil facial tumour 2 Sarcophilus harrisii Tasmanian devil Dft1 
UnknownTasman-PCR: a genetic diagnostic assay for Tasmanian devil facial tumour diseases.
Not available
S-EPMC6227955 | biostudies-literature
ProteomicsPassage of transmissible cancers in the Tasmanian devil is due to a dominant, shared peptide motif and a limited repertoire of MHC-I allotypes
Transmissible cancers are spread via the passage of malignant cells. The survival of the Tasmanian devil, the largest marsupial carnivore, is threatened by two independent transmissible cancers, devil facial tumour (DFT) 1 and devil facial tumour 2 (DFT2). To aid the development of a peptide vaccine...
ORGANISM(S): Sarcophilus harrisii 
2021-02-08 | PXD020614 | Pride
Contagious cancer Mhc Marsupial Transmissible cancer Tasmanian devil Immunopeptidome 
ProteomicsThe ERBB-STAT3 Axis Drives Tasmanian Devil Facial Tumor Disease
The marsupial Tasmanian devil (Sarcophilus harrisii) faces extinction due to transmissible devil facial tumor disease (DFTD). To unveil the culprit molecular underpinnings, we designed an approach that combines sensitivity to drugs with an integrated systems-biology characterization. Sensitivity to ...
ORGANISM(S): Sarcophilus harrisii 
2019-01-18 | PXD009283 | Pride
Tasmanian devil Dftd Transmissible cancer Erbb 
GenomicsTranscriptomes of two contagious cancers
RNAseq of two contagious cancer cell lines in the Tasmanian devil, Devil Facial Tumour 1 (DFT1) and Devil Facial Tumour 2 (DFT2)
PRJEB39603 | ENA
UnknownComparative Cytogenetic Mapping and Telomere Analysis Provide Evolutionary Predictions for Devil Facial Tumour 2.
Not available
S-EPMC7290341 | biostudies-literature
ProteomicsUncovering the pathways related with extracellular vesicles derived from Devil Facial Tumour cells (DFTD).
Tasmanian devils are threatened with extinction because of two genetically independent transmissible cancers which are termed as Devil Facial Tumour Disease one and two (DFTD-1 and DFTD-2). The cancers are indistinguishable by gross examination and require laboratory procedures such as immunohistoch...
ORGANISM(S): Sarcophilus harrisii 
2023-04-27 | PXD020766 | Pride
Proteomics Extracellular vesicles Biomarkers Dftd 
UnknownThe newly-arisen Devil facial tumour disease 2 (DFT2) reveals a mechanism for the emergence of a contagious cancer.
Not available
S-EPMC6092122 | biostudies-literature
ProteomicsInvestigation of signalling pathways and potential mechanisms of drug resistance associated with the two transmissible cancers in the Tasmanian devil using phosphoproteomics
Investigation of signalling pathways and potential mechanisms of drug resistance associated with the two transmissible cancers in the Tasmanian devil using phosphoproteomics Two transmissible cancers, Devil Facial Tumor 1 (DFT1) and Devil Facial Tumor 2 (DFT2), have caused significant declines in Ta...
ORGANISM(S): Sarcophilus harrisii 
2026-03-09 | PXD058352 | Pride
Kinase inhibitor resistance Receptor tyrosine kinase inhibition Tasmanian devils Transmissible cancer Xenograft Devil facial tumour disease Phosphoproteomics Pdgfr Erbb 
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