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MetabolomicsMulti-Omics Approach to Elucidate Cerebrospinal Fluid Changes in Dogs with Intervertebral Disc Herniation
Herniation of the intervertebral disc (IVDH) is the most common cause of neurological and intervertebral disc degeneration-related diseases. Since the disc starts to degenerate before it can be observed by currently available diagnostic methods, there is an urgent need for novel diagnostic approache...
2021-11-04 | MTBLS2689 | MetaboLights
ProteomicsTMT-based proteomic analysis of CSF in dogs with intervertebral disc herniation
In our study, MS-based high-resolution proteomic analysis of CSF have been employed in order to gain deeper insights into changes occurring during IVDH in dogs, monitoring the pathophysiological processes at the protein and metabolite levels. The proteomics study involved canine patients classified ...
ORGANISM(S): Canis familiaris (Dog) (Canis lupus familiaris) 
2021-11-25 | PXD024921 | Pride
Proteomics Intervertebral disc herniation Tmt Csf Dog 
ProteomicsCirculating Tenascin-C/-miR-155-5p identified as promising prognostic candidates of intervertebral disc herniation
Intervertebral disc (IVD) herniation is a complex and multifactorial condition with challenging diagnosis and limited therapeutic options, highlighting the need for reliable biomarkers to improve clinical decision-making. The aim of this study was to identify circulating prognostic biomarkers of IVD...
ORGANISM(S): Rattus norvegicus (Rat) 
2026-02-02 | PXD071649 | Pride
Disc herniation Proteomics Mirna Intervertebral disc Circulating biomarkers 
ProteomicsIntegrated with Proteome-sequencing, bulk RNA-sequencing and Single cell RNA-sequencing to identify potential biomarkers in different grades of intervertebral disc degeneration
We selected humann intervertebral disc samples to perform proteomics analysis. There were 1 case of grade I , 1 case of grade II, 3 cases of grade Ⅲ and 3 cases of grade Ⅳ according to Pfirrmann classfication. RNA seqencing analysis and single-cell RNA sequencing were integrated with proteomics data...
ORGANISM(S): Homo sapiens (Human) 
2023-05-10 | PXD040593 | Pride
Intervertebral disc degeneration Proteome-sequencing 
TranscriptomicsTranscription profiling of human intervertebral disc cells treated with varying osmolarity growth medium
Human intervertebral disc tissue was obtained from patients (average age 51 yrs) undergoing surgery for lumbar interbody fusion (n=3) or lumbar disc herniation (n=1). Cells were isolated by sequential pronase-collagenase digestion [3]. Cells were passaged twice in monolayer and suspended at a densit...
ORGANISM(S): Homo sapiens 
2007-08-13 | E-GEOD-1648 | biostudies-arrayexpress
GenomicsLumbar intervertebral disc mRNA sequencing identifies the regulatory pathway in patients with disc herniation and spondylolisthesis
Lumbar intervertebral disc mRNA sequencing identifies the regulatory pathway in patients with disc herniation and spondylolisthesis
PRJNA612336 | ENA
TranscriptomicsGenetic background and aging-driven neuroimmune and disc changes underscore herniation susceptibility and pain-associated behaviors in SM/J mice
SM/J mice experience spontaneous age-associated intervertebral disc herniations, with molecular analyses indicating a dysregulated immune system may contribute to this disc pathology. To investigate this, we analyzed the circulating immune cells of these mice during aging, in relation to BL/6 mice, ...
ORGANISM(S): Mus musculus 
2025-04-30 | GSE252474 | GEO
GenomicsGenetic background and aging-driven neuroimmune and disc changes underscore herniation susceptibility and pain-associated behaviors in SM/J mice
Genetic background and aging-driven neuroimmune and disc changes underscore herniation susceptibility and pain-associated behaviors in SM/J mice
PRJNA1060705 | ENA
UnknownA novel rat model of lumbar disc herniation induced by puncture: accurate positioning and controllable degree of herniation.
Not available
S-EPMC11934670 | biostudies-literature
UnknownTissue Engineering a Biological Repair Strategy for Lumbar Disc Herniation.
Not available
S-EPMC4652242 | biostudies-literature
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