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Proteomicsprm-PASEF and g-dia-PASEF analysis of plasma samples from colorectal cancer and control patients
Quantitative analysis of 10 CRC vs 10 control human plasma samples with the prm-PASEF and g-dia-PASEF acquisition methodes
ORGANISM(S): Homo sapiens (Human) 
2023-04-11 | PXD036594 | Pride
Pasef prm dia plasma colorectal cancer 
Proteomics¬Single cell transcriptomics of human iPSC differentiation dynamics reveal a core network of Parkinson’s disease
Parkinson’s disease (PD) is the second-most prevalent neurodegenerative disorder, characterized by the loss of dopaminergic neurons (mDA) in the midbrain. The underlying mechanisms are only partly understood and there is no treatment to reverse PD progression. Here, we investigated the disease mecha...
ORGANISM(S): Homo sapiens (Human) 
2022-02-15 | PXD028283 | Pride
Parkinson’s disease  ipscs Shotgun 
ProteomicsProteomic consequences of TDA1 deficiency in Saccharomyces cerevisiae
Hexokinase 2 (Hxk2) of Saccharomyces cerevisiae is a dual function hexokinase, acting as a glycolytic enzyme and being involved in the transcriptional regulation of glucose-repressible genes. Relief from glucose repression is accompanied by phosphorylation of Hxk2 at serine 15, which has been attrib...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2022-09-30 | PXD029824 | Pride
Hexokinase Prm 
ProteomicsNpr2-mediated cGMP signalling modulates S-palmitoylation and controls growth cone morphology of DRG neurons
A cGMP signalling cascade composed of the ligand C-type natriuretic peptide (CNP), the natriuretic peptide receptor 2 (Npr2) and the cGMP-dependent kinase Iα (cGKI) is implicated by growth cone splitting in the bifurcation of afferents from dorsal root ganglia (DRG), cranial sensory ganglia (CSG) an...
ORGANISM(S): Mus musculus (Mouse) 
2018-10-18 | PXD010326 | Pride
Ap-ms Cgmp signalling Shotgun 
ProteomicsMitochondrial One-Carbon Flux has a Growth-Independent Role in Promoting Breast Cancer Metastasis
Progression of primary cancer to metastatic disease is the most common cause of death in cancer patients with minimal treatment options available. Canonical drugs mainly target the proliferative capacity of cancer cells, which often leaves slow-proliferating, persistent cancer cells unaffected. Thus...
ORGANISM(S): Homo sapiens (Human) 
2022-06-09 | PXD027175 | Pride
Cancer Formate Human Metastasis 
ProteomicsEnzymatic activity of glycosyltransferase GLT8D1 promotes human glioblastoma cells migration
Glioblastoma (GBM) is the most aggressive primary brain tumor characterized by infiltrative migration of malignant glioma cells into the surrounding brain parenchyma. In this study, our analysis of GBM patient cohorts displayed significant higher expression of Glycosyltransferase 8 domain containing...
ORGANISM(S): Homo sapiens (Human) 
2022-04-04 | PXD027854 | Pride
Glioblastoma Q-exactive hf Human Glt8d1 Interactome 
ProteomicsEndothelial PKA targets ATG16L1 to regulate angiogenesis by limiting autophagy
The cAMP-dependent protein kinase A (PKA) regulates a plethora of cellular functions in health and disease. During angiogenesis, PKA activity in endothelial cells controls the transition from sprouting to vessel maturation and limits tip cell formation independently of Notch signaling. The molecular...
ORGANISM(S): Homo sapiens (Human) 
2019-10-04 | PXD012975 | Pride
Autophagy Pka Atg16l1 
ProteomicsBulk delivery of a preassembled apical surface initiates epithelial lumen formation
The creation of a microvilli-rich apical luminal domain is essential for epithelial tissue morphogenesis and is closely coordinated with the formation of the apical junctional complex (AJC). De novo lumenogenesis, in which epithelial cells establish apical identity by directing apical cargo to an ap...
ORGANISM(S): Canis familiaris (Dog) (Canis lupus familiaris) 
2026-06-08 | PXD061234 | Pride
Epithelial polarity 
ProteomicsSpatially restricted proteomics reveals dynamic changes in the caveolin-1 interactome in response to increased membrane tension
Here, we used APEX2 proximity labelling technique coupled with mass spectrometry to define Cveolin-1 interactome at steady state and after hypo-osmotic shock. We created a stable cell line expressing Caveolin1-APEX2-EGFP in human retinal pigmented epithelial cells (RPE-1). Hypo osmotic shock was per...
ORGANISM(S): Homo sapiens (Human) 
2024-11-05 | PXD026464 | Pride
Caveolin-1  apex2  interactome  membrane tension 
ProteomicsPan-claudin family interactome analysis reveals shared and specific interactions
Interactome study of the pan-claudin family by combining two complementary pull-down techniques followed by mass spectrometry to create an interaction landscape of the claudin family. Co-immunoprecipitation (CoIP) of recombinant claudins expressed in MDCK-C7 cells provided information about interact...
ORGANISM(S): Homo sapiens (Human) Canis familiaris (Dog) (Canis lupus familiaris) 
2023-10-24 | PXD031094 | Pride
Lc-ms/ms Prisma Claudin Pulldown Interactome Peptide pulldown 
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