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ProteomicsDNA polymerase kappa is the primary translesion synthesis polymerase for aldehyde ICLs
DNA interstrand crosslinks (ICLs) are highly cytotoxic lesions that block essential cellular processes like replication and transcription. Endogenous ICLs can be induced by reactive aldehydes produced during normal cellular metabolism. Defective repair of these aldehyde-induced ICLs is associated wi...
ORGANISM(S): Xenopus laevis (African clawed frog) 
2025-09-29 | PXD062134 | Pride
Acrolein-icl Fa pathway Acetaldehyde-icl Polymerase kappa Translesion synthesis 
ProteomicsCatalytic and non-catalytic functions of DNA polymerase kappa in translesion DNA synthesis
Translesion DNA synthesis (TLS) is a cellular process that enables the bypass of DNA lesions encountered during DNA replication and is emerging as a primary target of chemotherapy. Among vertebrate DNA polymerases, polymerase kappa (PolK) has the distinctive ability to bypass minor groove DNA adduct...
ORGANISM(S): Xenopus laevis (African clawed frog) 
2024-08-27 | PXD044258 | Pride
Xenopus Tls Polz Polk Rev1 Polymerase kappa Ubiquitin Translesion dna synthesis Pcna Dna replication 
ProteomicsDNA polymerase kappa is the primary translesion synthesis polymerase for aldehyde ICLs
DNA interstrand crosslinks (ICLs) are highly cytotoxic lesions that block essential cellular processes like replication and transcription. Endogenous ICLs can be induced by reactive aldehydes produced during normal cellular metabolism. Defective repair of these aldehyde-induced ICLs is associated wi...
ORGANISM(S): Xenopus laevis (African clawed frog) 
2025-09-29 | PXD066315 | Pride
Dna polymerase kappa Acrolein-icl Translesion synthesis Fanconi anemia pathway Acetaldehyde-icl 
GenomicsActivity of DNA polymerase kappa across the genome in human fibroblasts
Activity of DNA polymerase kappa across the genome in human fibroblasts
PRJNA1081783 | ENA
TranscriptomicsTranscription profiling of rat pancreatic beta-cells in response to cytokine exposure and NF-kappa B activation blocking
Type 1 diabetes mellitus results from an autoimmune destruction of pancreatic beta-cells. Based on findings suggesting NF-kappa B plays a role in beta cell apoptosis, we blocked NF-kappa B activation in cytokine-exposed FACS sorted beta cells by a recombinant adenovirus (AdI kappa B((SA)2)) containi...
ORGANISM(S): Rattus norvegicus 
2006-06-16 | E-CBIL-9 | biostudies-arrayexpress
UnknownBypass of N²-ethylguanine by human DNA polymerase κ.
Not available
S-EPMC3010520 | biostudies-literature
UnknownMammalian DNA Polymerase Kappa Activity and Specificity.
Not available
S-EPMC6695781 | biostudies-literature
TranscriptomicsAnalysis of genome rearrangements in S. cerevisiae strains with low levels of DNA polymerase alpha
The arrays in this series were used to analyze chromosome rearrangements resulting from the repair of double-strand breaks at fragile site 2 (FS2) on S. cerevisiae chromosome III. This site is broken under conditions of low DNA polymerase alpha, as described in Lemoine et al., Cell vol. 120, pp. 58...
ORGANISM(S): Saccharomyces cerevisiae 
2010-05-18 | E-GEOD-16502 | biostudies-arrayexpress
TranscriptomicsA DNA polymerase ? accessory protein, Mcl1, is required for propagation of centromere structures in fission yeast
Specialized chromatin exists at centromeres and must be precisely transmitted during DNA replication. The mechanisms involved in the propagation of these structures remain elusive. Fission yeast centromeres are composed of two chromatin domains: the central CENP-ACnp1 kinetochore domain and flanking...
ORGANISM(S): Schizosaccharomyces pombe 
2008-07-22 | E-GEOD-11102 | biostudies-arrayexpress
OtherActivity of DNA polymerase kappa across the genome in human fibroblasts
DNA polymerase kappa (PolK) is a specialized polymerase that has multiple cellular roles such as translesion DNA synthesis, replicating repetitive sequences, and nucleotide excision repair. We have developed a method for capturing DNA synthesized by PolK utilizing a PolK - specific substrate, N2-(4-...
ORGANISM(S): Homo sapiens 
2024-06-17 | GSE260451 | GEO
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