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ProteomicsIntegrative Structural Model of DNA-PK Synapsis
In non-homologous end joining repair of DNA double strand breaks, DNA dependent protein kinase catalytic subunit (DNA-PKcs) and Ku70/80 binds the free DNA ends forming the holoenzyme DNA-PK. DNA-PK synapses across the break to tether the broken ends in the initial long range synaptic complex. We gen...
ORGANISM(S): Homo sapiens (Human) 
2021-01-20 | PXD017931 | Pride
Dna-pk Hydrogen deuterium exchange Crosslinking 
TranscriptomicsSYCP2 recruits HORMAD2 for chromosome-axis-associated ATR signaling, unsynapsed chromatin silencing, and synapsis surveillance in meiosis
Meiotic progression in mammals is governed by tightly coordinated transcriptional programs and surveillance mechanisms that ensure the successful pairing, synapsis, and segregation of homologous chromosomes. In spermatocytes, homolog pairing is safeguarded by the pachytene checkpoint, whose mechanis...
ORGANISM(S): Mus musculus 
2026-06-18 | E-MTAB-16317 | biostudies-arrayexpress
UnknownDNA double-strand break end synapsis by DNA loop extrusion.
Not available
S-EPMC10079674 | biostudies-literature
ProteomicsHDX-MS analysis of the DNA-mKu interaction and dynamics
This project aims to decipher the DNA-protein interactions of the DNA end-binding protein mKu. In Mycobacterium tuberculosis and prokaryotes in general, Ku serves as the initiator of the non-homologous end-joining (NHEJ) DNA repair pathway. Using HDX-MS complemented with structural data, we investi...
ORGANISM(S): Mycobacterium tuberculosis H37Rv 
2026-01-19 | PXD060776 | Pride
Dna synapsis M.tuberculosis Nhej Ku 
UnknownSpontaneous DNA Synapsis by Forming Noncanonical Intermolecular Structures.
Not available
S-EPMC9144187 | biostudies-literature
UnknownThe essential elements for the noncovalent association of two DNA ends during NHEJ synapsis.
Not available
S-EPMC6688983 | biostudies-literature
UnknownThe DNA Damage Checkpoint Eliminates Mouse Oocytes with Chromosome Synapsis Failure.
Not available
S-EPMC5621520 | biostudies-literature
GenomicsBCAS2 and hnRNPH1 orchestrate alternative splicing for DNA double-strand break repair and synapsis in meiotic prophase I [RNAs-seq]
BCAS2 and hnRNPH1 orchestrate alternative splicing for DNA double-strand break repair and synapsis in meiotic prophase I [RNAs-seq]
PRJNA1070617 | ENA
UnknownMouse TEX15 is essential for DNA double-strand break repair and chromosomal synapsis during male meiosis.
Not available
S-EPMC2265566 | biostudies-literature
UnknownOligomerisation of Ku from Mycobacterium tuberculosis promotes DNA synapsis.
Not available
S-EPMC12658125 | biostudies-literature
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