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MetabolomicsDynamic utilization of low-molecular-weight organic substrates across a microbial growth rate gradient

AIM: Low-molecular-weight organic substances (LMWOSs) are at the nexus between micro-organisms, plant roots, detritus and the soil mineral matrix. The nominal oxidation state of carbon (NOSC) has been suggested as a potential parameter for modelling microbial uptake rates of LMWO...

2023-08-14 | MTBLS3558 | MetaboLights
MetabolomicsA statistical analysis of the effects of urease pre-treatment on the measurement of the urinary metabolome by gas chromatography–mass spectrometry
Urease pre-treatment of urine has been utilized since the early 1960s to remove high levels of urea from samples prior to further processing and analysis by gas chromatography–mass spectrometry (GC–MS). Aside from the obvious depletion or elimination of urea, the effect, if any, of urease pre-treatm...
2014-05-21 | MTBLS71 | MetaboLights
ProteomicsProteome wide screening for ubiquitination, ISGylation and NEDDylation sites in wildtype and ISG15 knockout mouse hearts after transverse aortic constriction
Hearts(left ventricles) were harvested from control wildtype and ISG15 knockout mice and wildtype and ISG15 knockout mice 4 weeks after pressure overload induced by transverse aortic constriction. Nano LC-MS/MS analysis was performedon left ventricle tissue following protein extraction, trypsin dige...
ORGANISM(S): Mus musculus (Mouse) 
2023-05-10 | PXD032267 | Pride
Isgylation Mouse K-e-gg motif Heart Ubiquitination Tac 
ProteomicsDesign principles for cyclin K molecular glue degraders
Molecular glue degraders are an effective therapeutic modality, but their design principles are not well understood. Recently, several unexpectedly diverse compounds were reported to deplete cyclin K by linking CDK12-cyclin K to the DDB1-CUL4-RBX1 E3 ligase. To investigate how chemically dissimilar ...
ORGANISM(S): Hordeum vulgare (Barley) 
2023-10-20 | PXD041836 | Pride
Ubiquitin Cdk12 Molecular glue Cr8 Cyclink Degrader 
UnknownRegulation of abiotic stress signalling by Arabidopsis C-terminal domain phosphatase-like 1 requires interaction with a k-homology domain-containing protein.
Not available
S-EPMC3841200 | biostudies-literature
MetabolomicsA polyamine-centric blood-based metabolite panel predictive of poor response to CAR T-cell therapy in large B cell lymphoma

Anti-CD19 chimeric antigen receptor (CAR) T-cell therapy for relapsed or refractory (r/r) large B-cell lymphoma (LBCL) results in durable response in only a subset of patients. MYC overexpression in LBCL tumors is associated with poor response to treatment. We tested whether a MYC-driven polyamin...

2022-10-31 | MTBLS5381 | MetaboLights
ProteomicsMetabolite-protein covariation architecture identifies a cysteine shunt regulating liver cholesterol
Protein regulation of metabolic processes is foundational to biology. Here we develop a mass spectrometry-based approach that leverages genetic diversity to nominate functional relationships between 285 metabolites and 11,868 proteins in living tissues. This Metabolite Protein Covariation Architectu...
ORGANISM(S): Mus musculus (Mouse) 
2025-07-28 | PXD065355 | Pride
Lrrc58 Metabolism Cdo1 Do mice Cysteine Lasso Proteomics 
UnknownDo Cohabitants Reliably Complete Questionnaires for Patients in a Terminal Cancer Stage when Assessing Quality of Life, Pain, Depression, and Anxiety?
Not available
S-EPMC8083839 | biostudies-literature
UnknownAntioxidant Therapy Reduces Oxidative Stress, Restores Na,K-ATPase Function and Induces Neuroprotection in Rodent Models of Seizure and Epilepsy: A Systematic Review and Meta-Analysis.
Not available
S-EPMC10376594 | biostudies-literature
UnknownDesign principles for cyclin K molecular glue degraders.
Not available
S-EPMC10746543 | biostudies-literature
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