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MetabolomicsMetabolome analysis via an HPLC-ESI-MS-based experimental and computational pipeline for chronic nephron toxicity profiling
Untargeted metabolomics has the potential to improve the predictivity of in vitro toxicity models and therefore may aid the reduction of expensive and laborious animal models. Here we describe a chronic nephrotoxicity study conducted on a human renal proximal tubular epithelial cell line (RPTEC/TERT...
2015-09-07 | MTBLS140 | MetaboLights
UnknownProteomics, Transcriptomics, and Phosphoproteomics Reveal the Mechanism of Talaroconvolutin-A Suppressing Bladder Cancer via Blocking Cell Cycle and Triggering Ferroptosis.
Not available
S-EPMC10696259 | biostudies-literature
UnknownIdentification of thalidomide-specific transcriptomics and proteomics signatures during differentiation of human embryonic stem cells.
Not available
S-EPMC3429450 | biostudies-literature
UnknownIntegrating transcriptomics and proteomics to show that tanshinone IIA suppresses cell growth by blocking glucose metabolism in gastric cancer cells.
Not available
S-EPMC4328042 | biostudies-literature
UnknownTranscriptomics and Proteomics Characterizing the Anticancer Mechanisms of Natural Rebeccamycin Analog Loonamycin in Breast Cancer Cells.
Not available
S-EPMC9611194 | biostudies-literature
TranscriptomicsTranscription profiling of Dictyostelium discoideum treated with mercury - a systems biology assessment of the model eukaryote Dictyostelium discoideum unveils compensatory responses and a critical role of the amino acid metabolic balance in the early phase of mercury induced cyto-toxicity
Gene expression alone is not able to characterize the physiological status of pollutant-challenged organisms. However, when transcriptomics is integrated with functional information, it becomes an extremely powerful tool, able to distinguish between compensatory and non-protective cytotoxic response...
ORGANISM(S): Dictyostelium discoideum 
2010-06-09 | E-TABM-710 | biostudies-arrayexpress
ProteomicsQuantitative proteomics of maize roots treated with a novel protein hydrolase: comparative study with transcriptomics highlights the molecular mechanisms responsive to biostimulants
Protein hydrolysates (PHs) - based biostimulants offer a cost-effective, and sustainable approach for the regulation of physiological processes in plants to stimulate growth, and improve stress tolerance. Understanding the mode of action of PHs is challenging however, it is indispensable to improve ...
ORGANISM(S): Zea mays (Maize) 
2020-11-16 | PXD017781 | Pride
Biostimulants Tmt Protein hydrolase Lc-ms/ms Maize roots 
ProteomicsHigh-dose oncogenic PIK3CA drives constitutive cellular stemness through increased NODAL/TGFb signaling
Oncogenic PIK3CA mutations activate phosphoinositide 3-kinase (PI3K) and are among the commonest somatic mutations in cancer and mosaic, developmental overgrowth disorders. We recently demonstrated that the ‘hotspot’ variant PIK3CAH1047R exerts striking allele dose-dependent effects on stemness in h...
ORGANISM(S): Homo sapiens (Human) 
2021-03-03 | PXD014719 | Pride
Proteomics Tfgb Nodal ipsc Cancer Transcriptomics Pik3ca 
ProteomicsExtracellular vesicle-associated transcriptomic and proteomic biomarkers show in vitro potential for vandetanib treatment monitoring in anaplastic thyroid cancer
Background: Anaplastic thyroid cancer (ATC) is an aggressive and rare disease. Rapid metastasis and limited promising treatments call for additional therapeutic options, including drug repurposing. The early spreading of ATC highlights the importance of rapid therapy success assessment, which could ...
ORGANISM(S): Homo sapiens (Human) 
2025-09-09 | PXD064007 | Pride
Anaplastic thyroid cancer Vandetanib Extracellular vesicles Dose-dependent transcriptomics and proteomics 
ProteomicsChronic low-dose ionising radiation rates affect the hippocampal phospho-proteome of synaptogenesis in an ApoE-/--Alzheimer mouse model over 300 days of exposure
Cognitive impairments are an important side effect after radiation exposure. Yet, it comes more and more into scientific focus that ionising radiation can resemble pathologies of neurodegenerative diseases such as Alzheimer´s. Here, we used a multidisciplinary approach to elucidate the effect of chr...
ORGANISM(S): Mus musculus (Mouse) 
2017-07-25 | PXD003969 | Pride
Synapse Proteomics Hippocampus Synaptic plasticity Dendritic spine Phospho-proteomics Creb 
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