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ProteomicsLiceaga / Aguilar-Toala chia seed protein hydrolysate antimicrobial peptides
Aguilar-Toala 2019: Investigators under Andrea Liceaga at Department of Food Science at Purdue University examined the proteomes of chia seeds for their anti-microbial properties and enzyme inhibition [doi:10.1007/s00726-020-02879-4 and doi:10.1007/s12602-020-09653-8]. They followed activity for di...
ORGANISM(S): Salvia Hispanica (ncbitaxon:49212) 
2021-02-12 | MSV000086856 | MassIVE
ProteomicsMechanisms associated with systemic effects of cancer
Cancer is considered as a disease of a specific organ, but its effects are felt throughout the body. The systemic effects of cancer can lead to weakness in muscles and heart, which hastens cancer-associated death. The majority of preclinical studies, including our own, on cancer-induced skeletal mus...
ORGANISM(S): Homo sapiens (Human) 
2023-05-10 | PXD034000 | Pride
Breast cancer Muscle stem cells Skeletal muscle Lc-msms. Mir-486 Cancer cell line Human Biomarker 
ProteomicsTumor tissue collection and processing under physioxia allows highly relevant detection of signaling networks and drug sensitivity of cancer cells
Preclinical studies of primary cancer cells are always done after tumors are removed from patients or animals at ambient atmospheric oxygen (O2, ~21%). However, O2 concentrations in organs are in the ~3-10% range, with most tumors in an hypoxic or 1-2% O2 environment in vivo. Although effects of O2 ...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-16 | PXD023133 | Pride
Mouse Tumor Lc-ms/ms 
MetabolomicsIntegrating genomics and multi‐platform metabolomics enables metabolite QTL detection in breeding‐relevant apple germplasm
Apple (Malus × domestica) has commercial and nutritional value, but breeding constraints of tree crops limit varietal improvement. Marker-assisted selection minimizes these drawbacks, but breeders lack applications for targeting fruit phytochemicals. To understand genotype-phytochemical associations...
2021-09-21 | MTBLS2327 | MetaboLights
ProteomicsTranslation rescue by targeting Ppp1r15a upstream open reading frame in vivo
The eIF2 initiation complex is central to maintaining a functional translation machinery. Extreme stress such as life-threatening sepsis exposes vulnerabilities in this tightly regulated system, resulting in an imbalance between the opposing actions of kinases and phosphatases on the main regulatory...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2022-09-28 | PXD030889 | Pride
Lcmsmsi Phoshporylation Ppp1r15a Uorf Kidney Eif2 initation complex Translation 
ProteomicsDistinguishing post-translational modifications in dominantly inherited FTD: FTLD-TDP Type A (GRN) versus Type B (C9orf72)
Frontotemporal dementias are neuropathologically characterized by frontotemporal lobar degeneration (FTLD). Intraneuronal inclusions of transactive response DNA-binding protein 43 kDa (TDP-43) are the defining pathologic hallmark of approximately half of the FTLD cases, being referred to as FTLD-TDP...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-04-12 | MSV000089242 | MassIVE
ProteomicsHypusine Biosynthesis in β Cells Links Polyamine Metabolism to Facultative Cellular Proliferation to Maintain Glucose Homeostasis
Deoxyhypusine synthase (DHPS) utilizes the polyamine spermidine to catalyze the hypusine modification of the mRNA translation factor eIF5A and promotes oncogenesis through poorly-defined mechanisms. Because germline deletion of Dhps is embryonically lethal, its role in normal postnatal cellular fun...
ORGANISM(S): Mus musculus (Mouse) 
2020-02-17 | PXD015424 | Pride
Polyamines Β cell Hypusine Proliferation 
Proteomics: Hypusine Biosynthesis in β Cells Links Polyamine Metabolism to Facultative Cellular Proliferation to Maintain Glucose Homeostasis
: Deoxyhypusine synthase (DHPS) utilizes the polyamine spermidine to catalyze the hypusine modification of the mRNA translation factor eIF5A and promotes oncogenesis through poorly-defined mechanisms. Because germline deletion of Dhps is embryonically lethal, its role in normal postnatal cellular f...
ORGANISM(S): Mus musculus (Mouse) 
2021-09-08 | PXD015414 | Pride
Polyamines Β cell Hypusine Proliferation 
ProteomicsCharacterization of BioID tagging systems in budding yeast and exploring the interactome of the Ccr4-Not complex
The modified E. coli biotin ligase BirA* was the first developed for proximity labeling of proteins (BioID). However, it has low activity at temperatures below 37 C, which reduces its effectiveness in organisms growing at lower temperatures, such as budding yeast. Multiple derivatives of the enzymes...
ORGANISM(S): Saccharomyces Cerevisiae (ncbitaxon:4932) 
2024-05-02 | MSV000094663 | MassIVE
ProteomicsProteomic changes following knockdown of DNA repair and redox signaling protein, APE1/Ref-1, under hypoxia conditions
Pancreatic cancer is a complex disease with a desmoplastic stroma, extreme hypoxia, and inherent resistance to therapy. Understanding the signaling and adaptive response of such an aggressive cancer is key to making advances in therapeutic efficacy and understanding disease progression. Redox factor...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD020515 | Pride
Transcription factor signaling Ape1/ref-1 Dna repair Pancreatic cancer Hypoxia 
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