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ProteomicsA synthetic non-histone substrate to study substrate targeting by the Gcn5 HAT and sirtuin HDACs
Gcn5 and sirtuins are conserved HAT and HDAC enzymes that were first characterised as regulators of gene expression via histone acetylation. Although histone tails are important substrates of these enzymes, they also target non-histone proteins in diverse processes. Previously, we used SILAC-based m...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2019-02-25 | PXD012608 | Pride
Saga Gcn5 Consensus sequence Synthetic biology Acetylation Ada3 Sirtuin 
ProteomicsDdp1 cooperates with Ppx1 to counter a stress response initiated by non-vacuolar polyphosphate
In diverse cells from bacterial to mammalian species, inorganic phosphate is stored in long chains called polyphosphates (polyP). These near universal polymers, ranging from 3 to thousands of phosphate moieties in length, are associated with molecular functions including energy homeostasis, protein ...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2022-02-04 | PXD031326 | Pride
Yeast Label-free Quantitative proteomics Lc-ms/ms 
ProteomicsProteomics analysis reveals a role for E. coli polyphosphate kinase in regulation of membrane structure and polymyxin resistance via the BasS-BasR two component system
Polyphosphates (polyP) are chains of inorganic phosphates that can reach 1000s of residues in length. In Escherichia coli, polyP is produced by the polyP kinase (PPK) and is thought to play a protective role during the response to cellular stress. However, the pathways impacted by PPK activity and p...
ORGANISM(S): Escherichia coli 
2024-02-14 | PXD043566 | Pride
Lc-msms Cell culture Bacteria Label-free quantification E. coli 
ProteomicsSIRT3 controls brown fat thermogenesis by deacetylation regulation of pathways upstream of UCP1 

Objective: Brown adipose tissue (BAT) is important for thermoregulation in many mammals. Uncoupling protein 1 (UCP1) is the critical regulator of thermogenesis in BAT. Here we aimed to investigate the deacetylation control of BAT and to investigate a possible functional connection between UCP1 and s...
ORGANISM(S): Mus musculus (Mouse) 
2019-04-18 | PXD013056 | Pride
Brown adipose tissue  thermogenesis  thermoregulation  mitochondria  uncoupling protein 1  sirtuin 3  acetylation  oxidative phosphorylation  fatty acid oxidation  acylcarnitines 
 
ProteomicsA broad response to intracellular long-chain polyphosphate in human cells
Polyphosphates (PolyP) are highly anionic, linear polymers composed of long chains of inorganic phosphates linked together by phosphoanhydride bonds. PolyP chains are found in all kingdoms of life, and play roles in phosphate homeostasis, cell growth, infection, and blood coagulation. Unlike in bact...
ORGANISM(S): Homo sapiens (Human) 
2020-09-24 | PXD018896 | Pride
Human Hek293t Lc-ms/ms 
UnknownFostamatinib for the treatment of warm antibody autoimmune hemolytic anemia: Phase 2, multicenter, open-label study.
Not available
S-EPMC9313871 | biostudies-literature
UnknownDissemination of Verona Integron-encoded Metallo-β-lactamase among clinical and environmental Enterobacteriaceae isolates in Ontario, Canada.
Not available
S-EPMC7596063 | biostudies-literature
UnknownExposure to fine particulate matter and temporal dynamics of episodic memory and depressive symptoms in older women.
Not available
S-EPMC7499893 | biostudies-literature
TranscriptomicsGene expression profiles of Calu-3 lung epithelial cells after neutrophil transmigration
Injury to the epithelium is integral to the pathogenesis of many inflammatory lung diseases, and epithelial repair is a critical determinant of clinical outcome. However, the signaling pathways regulating such repair are incompletely understood. Herein, we used in vitro and in vivo models to define ...
ORGANISM(S): Homo sapiens 
2011-08-27 | E-GEOD-31697 | biostudies-arrayexpress
TranscriptomicsSingle cell RNA sequencing of CellTagging lung organoids
Here, we used a lentiviral-based barcoding method (CellTagging) to lineage trace progenitor cells in a human lung organoid model. 21-day cultures were transduced for 7 days, fluorescence activated cell sorted for GFP+ expression, and regrown as sparsely plated cells for additional 30 days before seq...
ORGANISM(S): Homo sapiens 
2023-04-21 | E-MTAB-12753 | biostudies-arrayexpress
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