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NK cells are increasingly recognized for their modulation of adaptive T cell responses; however the mechanisms by which NK cells modulate immune responses in human are unclear. Here we report that NKp44+ NK cells regulate CD8+ T cell expansion in an HLA-DP haplotype-dependent process. HLA-DP express...
ORGANISM(S): Homo sapiens 
Diplodia sp. Dp 3 transcriptome - Dp 3-C.2
Diplodia sp. Dp 5 transcriptome - Dp 5-B.2
A high-throughput mass spectrometry analysis was used to identify more than 16,000 cell peptides bound to several HLA-DR and -DP class II molecules isolated from large amounts of two human cell lines (HOM-2 and JY).
ORGANISM(S): Homo sapiens (Human) 
2021-11-03 | PXD028006 | Pride
In the context of HLA-DP-mismatched allogeneic stem cell transplantation, mismatched HLA-DP alleles can provoke profound allo-HLA-DP-specific immune responses from the donor T-cell repertoire leading to graft-versus-leukemia effect and/or graft-versus-host disease in the patient. The magnitude of al...
ORGANISM(S): Homo sapiens (Human) 
2022-02-12 | PXD030591 | Pride
Pseudomonas sp. DP-17 Genome sequencing and assembly
Comparing the mRNA expression profiles of c-Myb deficient and c-Myb sufficient Tcra-/- DP thymocytes. Results provide insight into the role of c-Myb in the regulation of survival and differentiation during the pre-selection DP stage where c-Myb expression is abundant during T cell development. DP th...
ORGANISM(S): Mus musculus 
Diplodia sp. Dp 4 gene expression analysis - Dp 4-C transcriptome
Diplodia sp. Dp 1 gene expression analysis - Dp 1-A transcriptome
Analysis of the peptide repertoires eluted from different HLA-DP molecules expressed in HeLa cells co-expressing Invariant chain either with or without HLA-DM as components of the HLA class II processing machinery. Divergence of the immunopeptidomes and the impact of HLA-DM were investigated in rela...
ORGANISM(S): Homo sapiens (Human) 
2022-11-21 | PXD017154 | Pride
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