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TranscriptomicsA Role for Small RNAs in DNA Double-Strand Break Repair
Here we identify a novel class of small RNAs that are ~21-nucleotide in length and are produced from the sequences in the vicinity of DNA double strand break (DSB) sites in Arabidopsis and humans. We named them diRNAs for DSB-induced small RNAs. In Arabidopsis, the biogenesis of diRNAs requires the ...
ORGANISM(S): Arabidopsis thaliana 
2012-03-26 | E-GEOD-36338 | biostudies-arrayexpress
TranscriptomicsPost-replicative formation of cohesion is required for repair and induced by a single DNA break
Sister chromatid cohesion, established during replication by the protein complex Cohesin, is essential for both chromosome segregation and double-strand break (DSB) repair. Normally cohesion formation is strictly limited to the S-phase of the cell cycle, but DSBs can trigger cohesion also after DNA ...
ORGANISM(S): Saccharomyces cerevisiae 
2010-06-10 | E-GEOD-8270 | biostudies-arrayexpress
ProteomicsPDHE1α, PARylation, Acetyl-CoA, Acetylation, Histones, DNA damage repair
Chromatin relaxation is a prerequisite step that allows the DNA repair machinery to access double-strand breaks (DSBs), and local histones around the DNA breaks suffer from prompt acetylation changes. However, an intriguing question remains as to where the large demands of acetyl-CoA is precisely pr...
ORGANISM(S): Homo sapiens (Human) 
2023-07-27 | PXD040676 | Pride
Pdhe1α Acetyl-coa Dna damage repair Parylation Histones Acetylation 
TranscriptomicsTranscriptional effects of I-PpoI induced DNA double strand breaks in mouse lymphocytes
DNA double-strand breaks (DSBs) and their repair can cause extensive epigenetic changes. As a result, DSBs have been proposed to promote transcriptional and, ultimately, physiological dysfunction via both cell-intrinsic and cell-non-autonomous pathways. Studying the consequences of DSBs in higher or...
ORGANISM(S): Mus musculus 
2016-01-04 | E-GEOD-74855 | biostudies-arrayexpress
UnknownHELQ is a dual-function DSB repair enzyme modulated by RPA and RAD51.
Not available
S-EPMC8755542 | biostudies-literature
ProteomicsARID1A regulates chromatin organization and establishment of epigenetic marks for DSB repair and transcription silencing
AT-rich interactive domain-containing protein 1A (ARID1A), a SWI/SNF chromatin remodeling complex subunit, is frequently mutated across various cancer entities. ARID1A contributes to DNA damage response pathways, and we previously reported that ARID1A loss is associated with mutational signatures li...
ORGANISM(S): Homo sapiens (Human) 
2024-06-22 | PXD047225 | Pride
Dsb repair Epigenetic regulation Arid1a Chromatin 
TranscriptomicsMammalian PERIOD complex regulates repair of DSB in active chromatin through anchoring to the nuclear envelope
Repair of DNA Double Strand Breaks produced in transcriptionally active chromatin occurs through a mechanism, Transcription-Coupled DSB repair (TC-DSBR), that is yet poorly characterized. Here, using a screening approach scoring multiple outputs in human cells, we identified the PER complex, a key m...
ORGANISM(S): Homo sapiens 
2025-11-12 | E-MTAB-12712 | biostudies-arrayexpress
ProteomicsARID1A regulates chromatin organization and establishment of epigenetic marks for DSB repair and transcription silencing
AT-rich interactive domain-containing protein 1A (ARID1A), a SWI/SNF chromatin remodeling complex subunit, is frequently mutated across various cancer entities. ARID1A contributes to DNA damage response pathways, and we previously reported that ARID1A loss is associated with mutational signatures li...
ORGANISM(S): Homo sapiens (Human) 
2025-04-08 | PXD046159 | Pride
Epigenetics Hr Arid1a Dsb Chromatin 
UnknownSystematic analysis of linker histone PTM hotspots reveals phosphorylation sites that modulate homologous recombination and DSB repair.
Not available
S-EPMC6996138 | biostudies-literature
GenomicsMammalian PERIOD complex regulates repair of DSB in active chromatin through anchoring to the nuclear envelope
Mammalian PERIOD complex regulates repair of DSB in active chromatin through anchoring to the nuclear envelope
PRJEB101600 | ENA
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