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Genomicsm6A-seq profiling in Mettl3 Ctrl and dTAG-13 treated mESCs
m6A-seq profiling in Mettl3 Ctrl and dTAG-13 treated mESCs
PRJNA1266678 | ENA
Methylation profilingm6A-seq profiling in Mettl3 Ctrl and dTAG-13 treated mESCs
dTAG-13 treated METTL3_FKBP12(F36V) is sufficient to functionally deplete m6A methylation catalysed by METTL3/14 complex.
ORGANISM(S): Mus musculus 
2025-06-19 | GSE297888 | GEO
GenomicsRNA-seq analysis after the treatment with DMSO or dTAG-13 in TAL1-FKBP12 Jurkat cells
RNA-seq analysis after the treatment with DMSO or dTAG-13 in TAL1-FKBP12 Jurkat cells
PRJNA938079 | ENA
GenomicsRNA-seq analysis in TAL1-FKBP12 Jurkat cells after the treatment with DMSO, dTAG-13, GSI or combination drugs
RNA-seq analysis in TAL1-FKBP12 Jurkat cells after the treatment with DMSO, dTAG-13, GSI or combination drugs
PRJNA938080 | ENA
TranscriptomicsRNA-seq analysis after the treatment with DMSO or dTAG-13 in TAL1-FKBP12 Jurkat cells
RNA-seq analysis was performed in a TAL1-FKBP12 Jurkat cell line to analyze gene expression changes after dTAG-13 treatmentat at various time points (1h, 2h, 4h, 6h, 8h, 16h, 24h, 48h and 72h).
ORGANISM(S): Homo sapiens 
2023-11-20 | GSE225939 | GEO
ProteomicsWhole cell proteome of OCI-AML3 FKBP12(F36V) cells with dTAG-13 treatment
The nucleolar scaffold protein NPM1 acts as a multifunctional regulator of cellular homeostasis, genome integrity, and stress response. NPM1 mutations, known as NPM1c variants that promote its aberrant cytoplasmic localization, are the most frequent genetic alterations in acute myeloid leukemia (AML...
ORGANISM(S): Homo sapiens (Human) 
2023-10-28 | PXD045357 | Pride
Oci-aml3 dtag npm1c proteome 
ProteomicsCDK5-Cyclin B1 regulates mitotic progression and fidelity
Mammalian cell cycle is driven by several CDK-cyclin complexes, with CDK1/cyclin B1 (CCNB1) being the one that is essential for mitotic entry and progression. CDK5 is not considered a typical CDK due to its high expression in post-mitotic neurons and activation by non-cyclin proteins p35 and p39. We...
ORGANISM(S): Homo sapiens (Human) 
2025-08-04 | PXD038386 | Pride
Human Phosphopeptides Rpe1 Imac Tmt 1nm-pp1 Cdk5 Dtag-13 Brp fractionation Cell line Lc-ms/ms 
TranscriptomicsUse of the dTAG system in vivo to degrade CDK2 and CDK5 in adult mice and explore potential safety liabilities [Bone marrow]
The degradation tag (dTAG) system for target protein degradation can remove proteins from biological systems without the drawbacks of some genetic methods, such as slow kinetics, lack of reversibility, low specificity, and the inability to titrate dosage. These drawbacks can make it difficult to com...
ORGANISM(S): Mus musculus 
2023-05-28 | GSE226386 | GEO
TranscriptomicsUse of the dTAG system in vivo to degrade CDK2 and CDK5 in adult mice and explore potential safety liabilities [Duodenum]
The degradation tag (dTAG) system for target protein degradation can remove proteins from biological systems without the drawbacks of some genetic methods, such as slow kinetics, lack of reversibility, low specificity, and the inability to titrate dosage. These drawbacks can make it difficult to com...
ORGANISM(S): Mus musculus 
2023-05-28 | GSE226388 | GEO
TranscriptomicsRNA exonuclease REXO4 resolves m6A-marked R-loops and suppresses anti-tumor immunity [RNAseq in REXO4-dTAG HeLa cells]
To determine if REXO4 depletion directly induces R-loop accumulation independent of transcription, we generated a HeLa cell line expressing endogenous REXO4 tagged with an N-terminal HA-FKBP12/F36V degron (REXO4-dTAG) via microhomology-mediated end joining (MMEJ)-based CRISPR/Cas9. Acute REXO4 degra...
ORGANISM(S): Homo sapiens 
2026-05-28 | GSE313849 | GEO
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