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TranscriptomicsTranscriptional profiling of Neurospora crassa cells containing MAK2Q100G allele: Exposure to ATP-analog (1NM-PP1) vs control
To study the consequences of MAK-2 activity modulation during vegetative cell fusion, we took advantage of a previously constructed allele of MAK-2 (MAK-2Q100G) to specifically perturb kinase signaling during germling vegetative cell fusion (inhibition of MAK-2Q100G activity by addition of the ATP a...
ORGANISM(S): Neurospora crassa OR74A 
2013-06-01 | E-GEOD-46912 | biostudies-arrayexpress
UnknownIdentification of mutations in TgMAPK1 of Toxoplasma gondii conferring resistance to 1NM-PP1.
Not available
S-EPMC3862444 | biostudies-literature
UnknownUse of the kinase inhibitor analog 1NM-PP1 reveals a role for Toxoplasma gondii CDPK1 in the invasion step.
Not available
S-EPMC2863409 | biostudies-literature
TranscriptomicsTranscriptional profiling of Neurospora crassa cells containing MAK2Q100G allele: Exposure to ATP-analog (1NM-PP1) vs control
To study the consequences of MAK-2 activity modulation during vegetative cell fusion, we took advantage of a previously constructed allele of MAK-2 (MAK-2Q100G) to specifically perturb kinase signaling during germling vegetative cell fusion (inhibition of MAK-2Q100G activity by addition of the ATP a...
ORGANISM(S): Neurospora crassa OR74A Neurospora crassa 
2013-06-01 | GSE46912 | GEO
GenomicsNeurospora crassa OR74A
Transcriptional profiling of Neurospora crassa cells containing MAK2Q100G allele: Exposure to ATP-analog (1NM-PP1) vs control
PRJNA203019 | ENA
GenomicsSch9 regulates ribosome biogenesis via Stb3, Dot6 and Tod6 and the histone deacetylase complex RPD3L (ChIP-Seq data)
TORC1 is a structurally and functionally conserved multiprotein complex that regulates many aspects of eukaryote growth including the synthesis and assembly of ribosomes. The protein kinase activity of this complex is responsive to environmental cues and is potently inhibited by the natural product ...
ORGANISM(S): Saccharomyces cerevisiae 
2011-07-01 | E-GEOD-29124 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human fibrosarcoma cells to study the relative contributions of Jak1 and Jak2 in IFNg signaling
General impact of Jak1 and Jak2 inhibition on IFNg-mediated target gene expression. U4C-Jak1AS and g2A-Jak2AS cells were stimulated with IFNg and treated with either 1NM-PP1 (to inhibit the activity only of the analog-sensitive mutant) or JI1 (to suppress both wild-type and analog-sensitive Jaks) fo...
ORGANISM(S): Homo sapiens 
2011-03-14 | E-MEXP-2621 | biostudies-arrayexpress
ProteomicsChromatin transaction map during vertebrate mitotic entry
We have used a combination of chemical genetics, chromatin proteomics and imaging to map the earliest chromatin transactions during vertebrate cell entry into mitosis. Chicken DT40 Cdk1as cells undergo synchronous mitotic entry within 15 minutes following release from a 1NM-PP1-induced arrest in lat...
ORGANISM(S): Gallus gallus (Chicken) 
2022-01-31 | PXD026385 | Pride
Silac Chicken Chromatin Mitosis 
ProteomicsCDK5-Cyclin B1 regulates mitotic progression and fidelity
Mammalian cell cycle is driven by several CDK-cyclin complexes, with CDK1/cyclin B1 (CCNB1) being the one that is essential for mitotic entry and progression. CDK5 is not considered a typical CDK due to its high expression in post-mitotic neurons and activation by non-cyclin proteins p35 and p39. We...
ORGANISM(S): Homo sapiens (Human) 
2025-08-04 | PXD038386 | Pride
Human Phosphopeptides Rpe1 Imac Tmt 1nm-pp1 Cdk5 Dtag-13 Brp fractionation Cell line Lc-ms/ms 
TranscriptomicsSch9 regulates ribosome biogenesis via Stb3, Dot6 and Tod6 and the histone deacetylase complex RPD3L (mRNA-Seq data)
TORC1 is a structurally and functionally conserved multiprotein complex that regulates many aspects of eukaryote growth including the synthesis and assembly of ribosomes. The protein kinase activity of this complex is responsive to environmental cues and is potently inhibited by the natural product ...
ORGANISM(S): Saccharomyces cerevisiae 
2011-07-01 | E-GEOD-29122 | biostudies-arrayexpress
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