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ProteomicsCDK5-Cyclin B1 regulates mitotic progression and fidelity
Mammalian cell cycle is driven by several CDK-cyclin complexes, with CDK1/cyclin B1 (CCNB1) being the one that is essential for mitotic entry and progression. CDK5 is not considered a typical CDK due to its high expression in post-mitotic neurons and activation by non-cyclin proteins p35 and p39. We...
ORGANISM(S): Homo sapiens (Human) 
2025-08-04 | PXD038386 | Pride
Human Phosphopeptides Rpe1 Imac Tmt 1nm-pp1 Cdk5 Dtag-13 Brp fractionation Cell line Lc-ms/ms 
ProteomicsCyclin dependent kinase 5 (CDK5) regulates the circadian clock
We show that the cyclin-dependent kinase 5 (CDK5) regulates the mammalian circadian clock via phosphorylation of PER2. CDK5 phosphorylated PER2 at serine residue 394 (S394) as shown by an in vitro kinase assay.
ORGANISM(S): Mus musculus (Mouse) 
2019-12-04 | PXD012068 | Pride
Mouse In vitro kinase assay Phosphorylation Per2 
ProteomicsPhosphoproteomics reveal that phosphorylation of MTDH by CDK5 inhibits protein synthesis in microglia
Our findings identified 335 phosphorylation sites on 234 proteins as potential CDK5 substrates in microglia based on the reported sequence motif
ORGANISM(S): Mus Musculus 
2024-03-08 | PXD050465 |
GenomicsCdk5 drives formation of heterogeneous pancreatic neuroendocrine tumors.
Cdk5 drives formation of heterogeneous pancreatic neuroendocrine tumors.
PRJNA736305 | ENA
GenomicsCDK5 inhibition abrogates TNBC stem-cell property and enhances anti-PD-1 therapy
CDK5 inhibition abrogates TNBC stem-cell property and enhances anti-PD-1 therapy
PRJNA549437 | ENA
ProteomicsElucidating molecular mechanisms underlying brain metastasis-promoting function of Cdk5
To elucidate molecular mechanisms underlying brain metastasis-promoting function of Cdk5, two analyses were performed. In the first analysis, we screened for Cdk5 substrates in brain-seeking breast cancer cell lines 4T1.Br3 and T11.Br1, transfected with shRNA targeting Cdk5 mRNA (100% knockdown) or ...
ORGANISM(S): Mus musculus (Mouse) 
2024-06-28 | PXD053434 | Pride
Astrocytes Cdk5 Phosphorylation Brain metastasis Kinase T11 Conditioned media 4t1 
GenomicsCDK5-dependent phosphorylation and nuclear translocation of TRIM59 promotes macroH2A1 ubiquitination and tumorigenicity
CDK5-dependent phosphorylation and nuclear translocation of TRIM59 promotes macroH2A1 ubiquitination and tumorigenicity
PRJNA542104 | ENA
ProteomicsCdk5 and GSK3β inhibit fast endophilin-mediated endocytosis
Endocytosis mediates the cellular uptake of micronutrients and cell surface proteins. Parallel to Clathrin-mediated endocytosis, additional Clathrin-independent endocytic routes exist, including fast Endophilin-mediated endocytosis (FEME). The latter is not constitutively active but requires the act...
ORGANISM(S): Homo sapiens (Human) 
2021-05-28 | PXD021138 | Pride
Lc-ms 
TranscriptomicsCdk5 drives formation of heterogeneous pancreatic neuroendocrine tumors.
Pancreatic neuroendocrine tumors (PanNETs) are a heterogeneous population of neoplasms that arise from hormone-secreting islet cells of the pancreas and have increased markedly in incidence over the past four decades. Non-functional PanNETs, which occur more frequently than hormone-secreting tumors,...
ORGANISM(S): Mus musculus 
2021-06-10 | GSE176448 | GEO
GenomicsCDK5-dependent phosphorylation and nuclear translocation of TRIM59 promotes macroH2A1 ubiquitination and tumorigenicity
Despite the development of adjuvant therapies, glioblastoma (GBM) patients remain incurable and justify the urgent need of new therapies. CDK5 functions a critical role in GBM and is a potential target for GBM. However, the mechanism by which CDK5 promotes GBM tumorigenicity remains largely unknown....
ORGANISM(S): Homo sapiens 
2019-08-11 | GSE130949 | GEO
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