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MetabolomicsExposure to per- and polyfluoroalkyl substances associates with altered lipid profile of breast milk (Part 2)
Not available
ORGANISM(S): Homo sapiens 
ST001685 | MetabolomicsWorkbench
TranscriptomicsPER2 synchronizes mitotic expansion and decidual transformation of human endometrial stromal cells
Implantation is dependent on synchronized interactions between the conceptus and surrounding decidual cells but the involvement of clock genes in this process is not well understood. Circadian oscillations are predicated on transcriptional-translational feedback loops, which balance the activities o...
ORGANISM(S): Homo sapiens 
2015-09-16 | E-GEOD-62854 | biostudies-arrayexpress
ProteomicsCry1 and Per2 protein complex in mouse liver
This project aimed to profile interacting proteins of Cry1 and Per2 from mouse liver.
ORGANISM(S): Mus musculus (Mouse) 
2023-03-11 | PXD037841 | Pride
Mouse liver Cry1 Ip-ms/ms Per2 
TranscriptomicsNegative reciprocal regulation between Sirt1 and Per2 modulates the circadian clock and aging (microarray expression)
Sirtuin 1 (SIRT1) is involved in both aging and circadian-clock regulation, yet the link between the two processes in relation to SIRT1 function is not clear. Using Sirt1-deficient mice, we found that Sirt1 and Period 2 (Per2) constitute a reciprocal negative regulation loop that plays important rol...
ORGANISM(S): Mus musculus 
2016-08-08 | E-GEOD-54436 | biostudies-arrayexpress
TranscriptomicsDifferential Gene Regulation during murine in vivo heart ischemia comparing wildtype and Per2 deficient mice
Disruption of peripheral circadian rhyme pathways dominantly leads to metabolic disorders. Studies on circadian rhythm proteins in the heart indicated a role for Clock or Per2 in cardiac metabolism. In fact, Per2-/- mice have larger infarct sizes with a deficient lactate production during myocardial...
ORGANISM(S): Mus musculus 
2013-08-21 | E-GEOD-45818 | biostudies-arrayexpress
ProteomicsIdentification of Per2-associated proteins in oral squamous carcinoma cell using LC-MS/MS
To identify potential proteins interacting with Per2 in oral squamous carcinoma cells, we performed SDS-PAGE followed by LC-MS/MS analysis of FLAG-Per2 immunoprecipitated proteins in cell extracts from SCC25 cells transfected with the FLAG-Per2 plasmid.
ORGANISM(S): Homo Sapiens 
2025-03-19 | PXD062046 |
TranscriptomicsExpression data from white and brown adipose tissue (WAT and BAT) of per2-/- and control mice
We found that the circadian protein PER2 interacts with the nuclear receptor PPARgamma to repress its activity. PPARgamma is a master regulator of adipogenesis and lipid metabolism and is very abundant in adipose tissue. We used microarrays to detail the global program of gene expression in adipose ...
ORGANISM(S): Mus musculus 
2010-10-19 | E-GEOD-20165 | biostudies-arrayexpress
ProteomicsCyclin dependent kinase 5 (CDK5) regulates the circadian clock
We show that the cyclin-dependent kinase 5 (CDK5) regulates the mammalian circadian clock via phosphorylation of PER2. CDK5 phosphorylated PER2 at serine residue 394 (S394) as shown by an in vitro kinase assay.
ORGANISM(S): Mus musculus (Mouse) 
2019-12-04 | PXD012068 | Pride
Mouse In vitro kinase assay Phosphorylation Per2 
ProteomicsCircadian proteome atlas of wild-type and Per1-/-/Per2-/- mice models across eight organs
a circadian proteome atlas of eight organs, namely suprachiasmatic nucleus (SCN), hypothalamus (HPOA), liver (LIV), gall bladder (GBD), brown adipose tissue (BAT), kidney (KDN), heart (HEA) and muscle (MUS), from wild-type (WT) and Per1-/-/Per2-/- (DKO) mice housed under constant darkness and ad lib...
ORGANISM(S): Mus Musculus 
2023-11-28 | PXD047352 |
GenomicsTranscriptomic analysis of Per2-deficient neutrophils compared WT neutrophils following infection.
Transcriptomic analysis of Per2-deficient neutrophils compared WT neutrophils following infection.
PRJNA1022165 | ENA
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