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MetabolomicsSubcellular antibiotic visualization reveals a dynamic drug reservoir in infected macrophages
Tuberculosis, caused by the intracellular pathogen Mycobacterium tuberculosis, remains the world's deadliest infectious disease. Sterilizing chemotherapy requires at least 6 months of multidrug therapy. Difficulty visualizing the subcellular localization of antibiotics in infected host cells means t...
2020-12-07 | MTBLS959 | MetaboLights
TranscriptomicsGene expression during SMC cord morphogenesis
SMCs must undergo specialzed patterning during blood vessel stabilization. We used microarray analysis to identify differentially expressed genes as smooth muscle cells were induced to assemble into a network of elongated cords. Two time points (Day 0 and Day 8) and three biological replicates for e...
ORGANISM(S): Homo sapiens 
2011-04-17 | E-GEOD-21363 | biostudies-arrayexpress
ProteomicsQuantitative Profiling of Protein S-Glutathionylation during Nanoparticle-Induced Oxidative Stress
Quantitative profiling of protein s-glutathionylation (SSG) reveals redox-dependent regulation of macrophage function during nanoparticle-induced oxidative stress
ORGANISM(S): Mus musculus (Mouse) 
2016-08-02 | PXD003356 | Pride
Glutathionylation Ssg Macrophage Redox Nanoparticle 
TranscriptomicsThe role of carbon starvation in the induction of enzymes that degrade plant-derived carbohydrates in Aspergillus niger
Fungi are an important source of enzymes for saccharification of plant polysaccharides and production of biofuels. Understanding of the regulation and induction of expression of genes encoding these enzymes is still incomplete. To explore the induction mechanism, we analysed the response of the indu...
ORGANISM(S): Aspergillus niger 
2014-08-22 | E-GEOD-57315 | biostudies-arrayexpress
UnknownCardiovascular Disease in Survivors of Childhood Cancer: Insights Into Epidemiology, Pathophysiology, and Prevention.
Not available
S-EPMC6804893 | biostudies-literature
ProteomicsBarbed bone point chronology reveals an unexpected hiatus in the archaeology of Southern Scandinavia around 10,300 years BP
The extensive peat bogs of Southern Scandinavia have yielded rich Mesolithic archaeological assemblages, which has informed prehistoric studies for more than a century. Central to this has been the first recognizably Mesolithic culture, the Maglemose (c. 11,000 - 8,000 BP), first described in 1903 w...
ORGANISM(S): Cervus elaphus (Red deer) Alces alces (Eurasian elk) 
2020-10-13 | PXD018050 | Pride
Palaeoproteomics Lc-ms Maldi-tof Cervids Archaeology Bone points 
UnknownKi67 Proliferation Index as a Tool for Chemotherapy Decisions During and After Neoadjuvant Aromatase Inhibitor Treatment of Breast Cancer: Results From the American College of Surgeons Oncology Group Z1031 Trial (Alliance).
Not available
S-EPMC5455353 | biostudies-literature
ProteomicsU2OS Adhesion Isolations +/- CytochalasinD and Neomycin
U2OS cells preferentially utilise integrin alphaV beta5 in adhesion complexes when grown under standard cell culture conditions for 3 days. AlphaV beta5 can be found in both classical 'Focal' adhesions and in novel 'Reticular' adhesions that do not associate with F-actin or other known adhesion prot...
ORGANISM(S): Homo sapiens (Human) 
2019-06-03 | PXD008680 | Pride
Human Cytod Reticular U2os Proteomics 
ProteomicsHeLa and U2OS long term culture adhesion isolations
Integrin adhesion complexes have been previously isolated and analysed by mass-spectrometry from cells largely spread on matrix proteins over a couple of hours. Here we wished to determine the composition of adhesion complexes from cells cultured for 72 hours under standard cell culture conditions a...
ORGANISM(S): Homo sapiens (Human) 
2019-06-03 | PXD008645 | Pride
Human Cancer cell Proteomics Integrin Adhesion complex Cell culture 
TranscriptomicsRNA-Seq based characterization of long non-coding RNA involved in respiratory viruses pathogenesis
We aimed at systematically inferring the regulatory functions of host lncRNAs in response to influenza A virus (IAV) and severe acute respiratory syndrome coronavirus (SARS-CoV) in the mouse model, using a ‘guilt-by-association’ approach which relies on finding which lncRNAs have similar expression ...
ORGANISM(S): Mus musculus 
2014-05-05 | E-GEOD-52405 | biostudies-arrayexpress
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