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TranscriptomicsSingle-cell gene expression of lymph node B cell-interacting reticular cells
Efficient germinal center formation requires the coordinated movement of B cells between distinct regions of the B cell follicle where their fate and function is governed by the integration of cues from their interacting partners. While CXCL13 is known to be important for B cell chemoattraction and ...
ORGANISM(S): Mus musculus 
2020-05-12 | E-MTAB-8445 | biostudies-arrayexpress
TranscriptomicsType I interferon signaling in fibroblastic reticular cells prevents exhaustive activation of antiviral CD8+ T cells
Fibroblastic reticular cells (FRC) shape the organization of secondary lymphoid organs and actively promote the induction of immune responses by coordinating the interaction of innate and adaptive immune cells. However, the mechanisms underlying FRC functions during viral infections have remained la...
ORGANISM(S): Mus musculus 
2020-09-01 | E-MTAB-8906 | biostudies-arrayexpress
TranscriptomicsFibroblastic reticular cells in the spleen - total splenic Stroma cells - single cell RNAseq dataset 2
Splenic white pulp (WP) structures are underpinned by fibroblastic stromal cells (FSCs) to facilitate splenic compartmentalization and execute efficient immune responses. Although distinct WP FSCs exhibit various molecular traits, the origin and the hierarchical differentiation of different cell sub...
ORGANISM(S): Mus musculus 
2019-03-27 | E-MTAB-7703 | biostudies-arrayexpress
TranscriptomicsOrigin and differentiation trajectories of fibroblastic reticular cells in the splenic white pulp - single cell RNAseq dataset 1
Splenic white pulp (WP) structures are underpinned by fibroblastic stromal cells (FSCs) to facilitate splenic compartmentalization and execute efficient immune responses. Although distinct WP FSCs exhibit various molecular traits, the origin and the hierarchical differentiation of different cell sub...
ORGANISM(S): Mus musculus 
2019-03-27 | E-MTAB-7094 | biostudies-arrayexpress
GenomicsBulk RNA-seq of Fibroblastic Reticular Cells
Bulk RNA-seq of Fibroblastic Reticular Cells
PRJEB43610 | ENA
ProteomicsU2OS Adhesion Isolations +/- CytochalasinD and Neomycin
U2OS cells preferentially utilise integrin alphaV beta5 in adhesion complexes when grown under standard cell culture conditions for 3 days. AlphaV beta5 can be found in both classical 'Focal' adhesions and in novel 'Reticular' adhesions that do not associate with F-actin or other known adhesion prot...
ORGANISM(S): Homo sapiens (Human) 
2019-06-03 | PXD008680 | Pride
Human Cytod Reticular U2os Proteomics 
ProteomicsThe composition of reticular adhesions in RPMI-7951 and MDA-MB-435S melanoma cell lines and its comparison with the reticular adhesion composition following talin2 or KANK2 knockdown
Integrins bind extracellular matrix proteins and, when clustered, form integrin adhesion complexes (IACs) that connect to and regulate the cytoskeleton, shaping normal and tumour cell behaviour. In addition to well-known nascent adhesions, focal adhesions (FAs), fibrillar adhesions (FBs), and hemide...
ORGANISM(S): Homo sapiens (Human) 
2026-06-15 | PXD071922 | Pride
Reticular adhesions Kank2 Matrisome Adhesome Melanoma Rpmi-7951 cells Integrin alphavbeta5 Talin2 Mda-mb-435s cells 
GenomicsRNA sequencing of splenic reticular cells in healthy and LCMV-infected mice
RNA sequencing of splenic reticular cells in healthy and LCMV-infected mice
PRJNA718476 | ENA
GenomicsMolecular profiling of reticular gigantocellularis neurons
Molecular profiling of reticular gigantocellularis neurons
PRJNA475266 | ENA
TranscriptomicsSingle cell RNAseq analysis of fibroblastic reticular cells from murine brachial lymph nodes during inflamed and resting states
The lymph node is home to resident macrophage populations that are essential for healthy immune function and homeostasis. They are involved in multiple processes including the initiation of the local response to pathogens, halting viral and bacterial spread, and clearance of apoptotic cells, but the...
ORGANISM(S): Mus musculus 
2023-05-01 | E-MTAB-10908 | biostudies-arrayexpress
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