Sort   by:  
 Page size 
ProteomicsA quantitative proteomic based approach to study the genistein induced epigenetic reprogramming in MDA-MB231 cells
Epidemiological data indicate that consumption of soy-based food significantly reduces the cancer risk in human through interaction with estrogen receptors and the ‘phytoestrogen’ genistein present in the soy is responsible for this chemopreventive activity. The epigenome regulatory effect of genist...
ORGANISM(S): Homo sapiens (Human) 
2018-07-05 | PXD006178 | Pride
Epigenome Epigenetics Dna repair Tmt Genistein Chromatome Heterochromatin Epigenetic reprogram Euchromatin Quantitative proteomics Chromatin 
ProteomicsQuantitative proteomic analysis of simian primary hepatocytes reveals candidate molecular markers for permissiveness to relapsing malaria Plasmodium cynomolgi
A major obstacle in deciphering the hepatic stage of the malaria parasite has been the challenges associated with culturing the infected hepatocytes through the entire liver stage cycle, including that of the dormant form known as hypnozoites. Primary hepatocytes lose their specialized functions in ...
ORGANISM(S): Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 
2019-09-02 | PXD013310 | Pride
Tmt Drug assay model development Quantitative proteomic Permissiveness to infection Malaria liver stage Biomarker Lc-ms/ms 
ProteomicsUncovering nutrient-regulated surface proteins using stable isotope labeling with amino acids in cell culture (SILAC) proteomics
The presence of a protein at the cell surface is regulated by the exocytic and endocytic membrane trafficking pathways. We have recently discovered that the nutrient, or amino acids, plays a substantial role in promoting the endocytic membrane trafficking. Here we ask if the nutrient can regulate t...
ORGANISM(S): Homo sapiens (Human) 
2019-04-03 | PXD011136 | Pride
Membrane trafficking Surface protein Silac Lc-ms/ms 
ProteomicsProteomics analysis of amyloid corneal aggregates from lattice corneal dystrophy patients
TGFBI associated Corneal Dystrophies (CD) are a group of inherited protein folding disorders linked to the mutation in the TGFBI gene. The resultant mutant protein (TGFBIp) is deposited as insoluble protein aggregates in various layers of the cornea leading to corneal opacity and poor vision. Depen...
ORGANISM(S): Homo sapiens (Human) 
2022-02-28 | PXD006640 | Pride
Corneal dystrophy Tgfbip Laser capture microdissection Amyloid fibrils Tgfbi Lattice corneal dystrophy Htra1 Apolipoprotein 
Sort   by:  
 Page size