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MetabolomicsBacillus subtilis inhibits African swine fever virus infection in vivo and in vitro based on its metabolites arctiin and genistein interfering with the function of viral topoisomerase II

African swine fever virus (ASFV) is an infectious disease with a mortality rate of nearly 100% in pigs; however, no safe commercial vaccines or antiviral drugs are currently available, which seriously threatens the global pig industry. Therefore, effective biologicals against ASFV are urgently ne...

2023-11-01 | MTBLS6586 | MetaboLights
TranscriptomicsExpression data from Human Ishikawa cells treated with Genistein
This study provides a comprehensive evaluation of changes in gene expression during treatment with Genistein in vitro. Ishikawa cells were maintained and grown (to confluency or at a desired cell density between 500,000 - 1 million cells/mL) in DMEM/F-12 Medium (supplemented with 10% Fetal Bovine Se...
ORGANISM(S): Homo sapiens 
2016-07-22 | E-GEOD-71717 | biostudies-arrayexpress
TranscriptomicsA comparative analysis of genistein and daidzein in affecting lipid metabolism in rat liver
Effects of soy isoflavones, genistein and daidzein, on the hepatic gene expression profile and indices for lipid metabolism were compared in rats. The GeneChip data was normalized and summarized by using SuperNORM data service (Skylight Biotech Inc.). Significance of expressional change among groups...
ORGANISM(S): Rattus norvegicus 
2012-10-10 | E-GEOD-41420 | biostudies-arrayexpress
TranscriptomicsComparison of B. japonicum mutant strain 613 induced versus wild type uninduced
An initializing step in the rhizobia-legume symbiosis is the secretion of flavonoids by plants that leads to the expression of nodulation genes in rhizobia. Here we report the genome-wide transcriptional response of Bradyrhizobium japonicum to genistein, an isoflavone secreted by soybean. About 100 ...
ORGANISM(S): Bradyrhizobium japonicum 
2007-10-15 | E-GEOD-8572 | biostudies-arrayexpress
TranscriptomicsResponse of Bradyrhizobium japonicum wild type and mutant strains to genistein
This SuperSeries is composed of the following subset Series: GSE8570: Comparison of B. japonicum mutant strain Δ901 induced versus wild type uninduced GSE8571: Comparison of B. japonicum 110spc4 (wild type) induced versus uninduced GSE8572: Comparison of B. japonicum mutant strain 613 induced versus...
ORGANISM(S): Bradyrhizobium japonicum 
2007-10-15 | E-GEOD-8580 | biostudies-arrayexpress
TranscriptomicsComparison of B. japonicum mutant strain M-NM-^T901 induced versus wild type uninduced
An initializing step in the rhizobia-legume symbiosis is the secretion of flavonoids by plants that leads to the expression of nodulation genes in rhizobia. Here we report the genome-wide transcriptional response of Bradyrhizobium japonicum to genistein, an isoflavone secreted by soybean. About 100 ...
ORGANISM(S): Bradyrhizobium japonicum 
2007-10-14 | E-GEOD-8570 | biostudies-arrayexpress
ProteomicsA quantitative proteomic based approach to study the genistein induced epigenetic reprogramming in MDA-MB231 cells
Epidemiological data indicate that consumption of soy-based food significantly reduces the cancer risk in human through interaction with estrogen receptors and the ‘phytoestrogen’ genistein present in the soy is responsible for this chemopreventive activity. The epigenome regulatory effect of genist...
ORGANISM(S): Homo sapiens (Human) 
2018-07-05 | PXD006178 | Pride
Epigenome Epigenetics Dna repair Tmt Genistein Chromatome Heterochromatin Epigenetic reprogram Euchromatin Quantitative proteomics Chromatin 
TranscriptomicsGenistein and bisphenol A exposure cause estrogen receptor 1 to bind thousands of binding sites in a cell type-specific manner
To obtain an integrated view of gene regulation in response to environmental and endogenous estrogens on a genome-wide scale, we performed ChIP-seq, to identify estrogen receptor 1 (ER) binding sites, and RNA-seq in endometrial cancer cells exposed to bisphenol A (BPA; found in plastics), genistein ...
ORGANISM(S): Homo sapiens 
2012-06-13 | E-GEOD-38234 | biostudies-arrayexpress
ProteomicsQuantitative Phosphoproteomics Reveals Genistein as a Modulator of Cell Cycle and DNA Damage Response Pathways
Around one sixth of breast cancer cases are classified as triple-negative breast cancer (TNBC), named after the absence of the expression of estrogen receptors (ER), progesterone receptors (PR), and human epidermal growth factor receptor 2 (HER2); however, patients with TNBC suffer from poor clinica...
ORGANISM(S): Homo sapiens (Human) 
2016-01-26 | PXD002735 | Pride
Atr Genistein Mda-mb-231 Ckd1 Triple negative breast cancer Lc-ms/ms Phosphorylation 
TranscriptomicsComparison of B. japonicum 110spc4 (wild type) induced versus uninduced
An initializing step in the rhizobia-legume symbiosis is the secretion of flavonoids by plants that leads to the expression of nodulation genes in rhizobia. Here we report the genome-wide transcriptional response of Bradyrhizobium japonicum to genistein, an isoflavone secreted by soybean. About 100 ...
ORGANISM(S): Bradyrhizobium japonicum 
2007-10-15 | E-GEOD-8571 | biostudies-arrayexpress
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