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TranscriptomicsIdentification of regulator of DYRK2
We used microarrays to identified new factor that regulates key factors in siRNA DYRK2 cells. We silenced DYRK2 in MCF-7 cells (siDYRK2 cells) using siRNA. For control, non-silencing siRNA was used. We obtained expression profiles from siDYRK2 cells and sControl cells.
ORGANISM(S): Homo sapiens 
2016-08-23 | E-GEOD-75917 | biostudies-arrayexpress
TranscriptomicsDYRK2 regulates cancer stem cell population.
We used microarrays to identified new factor that regulates cancer stem cell population in shRNA DYRK2 cells using stable DYRK2 knockdown cells and mammosphere. We stably silenced DYRK2 in MCF-7 cells (shRNA-DYRK2 cells) using pSuper vector. For control, pSuper control cells were created. We obtai...
ORGANISM(S): Homo sapiens 
2016-08-23 | E-GEOD-75918 | biostudies-arrayexpress
GenomicsDYRK2 gene transfer suppresses liver tumorigenesis
DYRK2 gene transfer suppresses liver tumorigenesis
PRJNA883685 | ENA
GenomicsDYRK2 knockout mice exhibit fetal growth retardation
DYRK2 knockout mice exhibit fetal growth retardation
PRJNA611501 | ENA
ProteomicsMulti-layered proteomic analyses decode compositional and functional effects of cancer mutations on kinase complexes
With the rapidly increasing availability of genomic data and ensuing identification of disease associated mutations, the determination of molecular mechanisms by which such mutations affect biochemical processes and phenotypes remains a major challenge. In this study we developed and applied a multi...
ORGANISM(S): Homo sapiens (Human) 
2020-07-22 | PXD015687 | Pride
Human Prm Dyrk2 Swath-ms Dda Cancer mutations 
ProteomicsInteractome of DYRK2 by using BioID proximity labeling
In this study, DYRK2 was found to be an important regulator of Hedgehog signaling. To identify DYRK2 interacting proteins, we performed interactome using BioID proximity labeling. NIH3T3 cells containing Dox-inducible DYRK2-BioID2-HA construct were cultured in the media with or without Doxycycline ...
ORGANISM(S): Mus Musculus (mouse) 
2024-07-01 | PXD043445 | JPOST Repository
TranscriptomicsDYRK2 gene transfer suppresses liver tumorigenesis
We generated liver-specific Dyrk2 knockout mice mating Dyrk2 flox mice with Alb-cre mice and co-introduced SB13-transposase-, myrAkt-, Myc- and mutant Hras-expressing plasmids with either HA- or Dyrk2-expressing plasmid into the knockout mice by HTVi. Dyrk2-expressing suppressed tumorigenesis compar...
ORGANISM(S): Mus musculus 
2022-09-24 | GSE214053 | GEO
TranscriptomicsDYRK2 regulates cancer stem cell population.
We used microarrays to identified new factor that regulates cancer stem cell population in shRNA DYRK2 cells using stable DYRK2 knockdown cells and mammosphere.
ORGANISM(S): Homo sapiens 
2016-08-23 | GSE75918 | GEO
TranscriptomicsDYRK2 knockout mice exhibit fetal growth retardation
We generated DYRK2-deficient mice using the CRISPR/Cas9 genome editing method and demonstrated that loss of DYRK2 gene causes fetal growth retardation and neonatal lethality at birth. Total RNA from DYRK2-/- whole embryo was compared with those of WT mice by microarray.
ORGANISM(S): Mus musculus 
2020-04-27 | GSE146614 | GEO
GenomicsPositive regulation of Hedgehog signaling via phosphorylation of GLI2/GLI3 by DYRK2 kinase
Positive regulation of Hedgehog signaling via phosphorylation of GLI2/GLI3 by DYRK2 kinase
PRJNA1112786 | ENA
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