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ModelsYan2012 - Rb-E2F pathway dynamics with miR449
MiRNAs, which are a family of small non-coding RNAs, regulate a broad array of physiological and developmental processes. However, their regulatory roles have remained largely mysterious. E2F is a positive regulator of cell cycle progression and also a potent inducer of apoptosis. Positive feedback ...
2024-09-02 | BIOMD0000000720 | BioModels
ProteomicsO-GlcNAcylation of FOXK1 orchestrates the E2F pathway
Gene transcription is a highly regulated process, and deregulation of transcription factors activity underlie numerous pathologies including cancer. FOXK1 and FOXK2 (FOXK1/2) transcription factors have recently emerged as important regulators of cell metabolism, autophagy and cell differentiation. W...
ORGANISM(S): Homo sapiens (Human) 
2024-06-10 | PXD050014 | Pride
E2f pathway O-glcnacylation Foxk1 
TranscriptomicsTranscription profiling of human melanoma cell line after Adenovirus-mediated E2F-1 gene transfer
E2F-1 gene expression profiling by adenovirus-mediated gene transfer in SKMEL-2 melanoma cell line.
ORGANISM(S): Homo sapiens 
2008-06-11 | E-GEOD-1562 | biostudies-arrayexpress
ProteomicsWidespread cancer relevant splicing events driven by the pRb-E2F pathway
E2F is a family of master transcription regulators involved in mediating diverse cell fates, and loss of control of the pathway is regarded as a hallmark of cancer. Recent studies have highlighted the pRb-E2F axis as a regulator of a large cellular network, which in addition to its classical target ...
ORGANISM(S): Homo sapiens (Human) 
2026-02-09 | PXD056505 | Pride
Rb Splicing factor E2f Alternative splicing Dp 
TranscriptomicsTranscription profiling of human SK-MEL-2 melanoma cell line transfected with E2F-1 and doxorubicin or transfected with a LacZ control plus doxorubicin to investigate the molecular mechanisms of a combination of E2F-1 gene therapy and chemotherapy.
SK-MEL-2 cells treated with Ad-E2F-1 (MOI 2), Ad-E2F-1 (MOI 2)plus doxorubicin 0.1uM, or Ad-LacZ (MOI 2) plus doxorubicin 0.1uM. The combination of E2F-1 gene therapy and chemotherapy produces a synergistic effect on melanoma cell apoptosis. However, the molecular mechanisms have not been fully eluc...
ORGANISM(S): Homo sapiens 
2007-10-27 | E-GEOD-2715 | biostudies-arrayexpress
TranscriptomicsIn vivo disruption of Rb-E2F-Ezh2 signaling loop causes bladder cancer development
Bladder cancer (BC) is a highly prevalent human disease in which Rb pathway inactivation and epigenetic alterations are common events. However, the connection between these two processes is still poorly understood. Here we show that the in vivo inactivation of all Rb family genes in the mouse urothe...
ORGANISM(S): Homo sapiens 
2014-10-02 | E-GEOD-38264 | biostudies-arrayexpress
ProteomicsThe RB/E2F pathway controls expression of the cancer genomic DNA deaminase APOBEC3B
Mutations in cancer are due in part to DNA cytosine deamination by APOBEC3B (A3B). While low in healthy tissues, A3B expression and activity are elevated in tumors and further increase in metastases. However, molecular mechanisms responsible for A3B transcriptional regulation are poorly understood. ...
ORGANISM(S): Homo sapiens (Human) 
2020-10-19 | PXD020473 | Pride
Cancer Silac Dna pull-down Polyoma virus t antigen Apobec3b 
TranscriptomicsMMTV-Myc tumor development in E2F-null backgrounds
Advances in genomic signatures have begun to dissect breast cancer heterogeneity, and application of these signatures will allow the prediction of which pathways are important in tumor development. Here we used genomic signatures to predict involvement of specific E2F transcription factors in Myc-i...
ORGANISM(S): Mus musculus 
2011-12-29 | E-GEOD-24594 | biostudies-arrayexpress
TranscriptomicsMulticilin drives centriole biogenesis via E2f proteins
Biochemistry suggests e2f4 forms a complex with the coiled-coiled protein multicilin (MCIDAS), a protein that is necessary and sufficient to specify multiciliated cells in vertebrates. Here, we performed RNAseq on Xenopus laevis ectoderm in the presence of multicilin alone or multicilin and a domina...
ORGANISM(S): Xenopus laevis 
2014-07-10 | E-GEOD-59309 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Drosophila E2f/Rb genetic pathway manipulation
We demonstrate that the cell cycle regulators, E2f /Dp and Rb, control the transcription of ribosomal proteins (RP) in Drosophila embryos. Mutation of E2f1 or Dp and over expression of Rbf1 increase and reduce RP transcription, respectively. Although E2f/Dp/Rb might exert this effect through a rep...
ORGANISM(S): Drosophila melanogaster 
2008-06-15 | E-GEOD-7655 | biostudies-arrayexpress
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