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MetabolomicsInvestigating the Impact of Acinetobacter lwoffii-ECT1/E6E7 Co-culture Metabolites on Cervical Cell Proliferation and Apoptosis via Untargeted Metabolomics.

This study employed untargeted metabolomics detection combined with bioinformatics analysis to investigate the metabolites from the co-culture of Acinetobacter lwoffiiand cervical precancerous cells ECT1/E6E7. A. lwoffiiwas co-cultured with ECT1/E6E7 cells at an MOI of 100. The culture supernatan...

2025-12-17 | MTBLS13526 | MetaboLights
ProteomicsStructural dynamics of the E6AP/UBE3A-E6-p53 enzyme-substrate complex
Deregulation of the ubiquitin ligase E6AP is causally linked to the development of human disease, including cervical cancer. In complex with the E6 oncoprotein of human papillomaviruses, E6AP targets the tumor suppressor p53 for degradation, thereby contributing to carcinogenesis. Moreover, E6 acts ...
ORGANISM(S): Human papillomavirus type 16 Homo sapiens (Human) 
2018-10-23 | PXD010002 | Pride
Xl-ms E6 oncoprotein Ubiquitin E6ap/ube3a P53 Papillomavirus 
GenomicsEscherichia coli strain:E6
Escherichia coli strain:E6 Genome sequencing and assembly
PRJNA804600 | ENA
GenomicsMetarhizium anisopliae strain:E6
Metarhizium anisopliae strain:E6 Genome sequencing and assembly
PRJNA1277033 | ENA
GenomicsEchovirus E6
Echovirus E6
PRJNA345663 | ENA
ProteomicsA dedicated ubiquitin-K48/63R variant-based affinity approach specifically identifies both high-risk and low-risk substrates of the HPV E6-E6AP ubiquitin ligase complex
To identify potential substrate proteins of both low risk and high risk E6 proteins, we established an affinity-based enrichment approach using a dedicated biotin-tagged ubiquitin variant that in the absence of the E6 proteins, cannot or only poorly be used by E6AP for ubiquitination. Enriched prote...
ORGANISM(S): Homo sapiens (Human) 
2020-08-31 | PXD017335 | Pride
E6 Ube3a E6-e6ap ubiquitin ligase Hpv-16 Human papillomavirus (hpv) Hpv-11 
GenomicsChlorocebus sabaeus strain:Vero E6
Chlorocebus sabaeus strain:Vero E6 Genome sequencing and assembly
PRJNA1111119 | ENA
TranscriptomicsTransgenic SCLC induced by E6/E7 oncoproteins vs normal controls
The human papillomavirus virus (HPV) is a proven cause of most human cervical cancers, and might have a role in other malignancies including vulva, skin, oesophagus, head and neck cancer. HPV has also been speculated to have a role in the pathogenesis of lung cancer. To validate the hypothesis of HP...
ORGANISM(S): Mus musculus 
2014-05-27 | E-GEOD-23962 | biostudies-arrayexpress
GenomicsAspergillus caperatus strain:DTO 337-E6 | isolate:DTO 337-E6
Aspergillus capperatus DTO 337-E6 Transcriptome - FGS 401
PRJNA708583 | ENA
GenomicsCellulophaga sp. E6(2014)
Cellulophaga sp. E6(2014) Genome sequencing and assembly
PRJNA245836 | ENA
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