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ProteomicsCell-selective proteomics segregates pancreatic cancer subtypes by extracellular proteins in tumors and circulation
Cell-selective proteomics is emerging as a powerful concept for studying heterocellular processes. However, its potential to dissect intercellular signaling has not been exploited, despite its promise to identify non-cell autonomous disease mechanisms or biomarkers. Here, we devised an improved azi...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2022-08-15 | PXD018659 | Pride
Proteomics Cell-selective Azidonorleucine Secretomics Serum Mouse Tumor Lc-msms Pdac Pancreatic cancer Extracellular matrix 
ProteomicsCell-selective proteomics segregates pancreatic cancer subtypes by extracellular proteins in tumors and circulation
Cell-selective proteomics is emerging as a powerful concept for studying heterocellular processes. However, its potential to dissect intercellular signaling has not been exploited, despite its promise to identify non-cell autonomous disease mechanisms or biomarkers. Here, we devised an improved azid...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2023-07-20 | PXD040084 | Pride
Submitter keyword: lc-msms Proteomics Cell-selective Azidonorleucine Secretomics Serum Mouse Tumor Pdac Pancreatic cancer Extracellular matrix 
ProteomicsIdentification of Covalent Modifications Regulating Immune Signaling Complex Composition and Phenotype
Cells signal through rearrangements of protein communities governed by covalent modifications and reversible interactions of distinct sets of proteins. A method that identifies those post-transcriptional modifications regulating signaling complex composition and functional phenotypes in one experime...
ORGANISM(S): Homo sapiens (Human) 
2021-07-07 | PXD010996 | Pride
Human Ap-ms Tlr2 Methylation Monocytes Acetylation Phosphorylation 
ProteomicsCholesterol sensing by CD81 is important for hepatitis C virus entry
CD81 is a protein found in the cells of all vertebrates, including humans. CD81 performs an important role in the natural biology of a cell: it organises collections of proteins at the cell surface, allowing them to function together. Through this role, CD81 facilitates the activation of immune cell...
ORGANISM(S): Homo sapiens (Human) 
2020-12-02 | PXD019260 | Pride
Proteomics Immune cell Hepatitis c Signal transduction Cd81 Mass spectrometry 
ProteomicsBenefit of circadian clocks in adaptive immunity and vaccination responses
The adaptive immune response is under circadian control, yet, the benefit of this rhythmicity for the organism is unknown. Furthermore, it is not understood why adaptive immune reactions continue to exhibit circadian changes over long periods of time. Using a combination of experimental and mathemat...
ORGANISM(S): Mus musculus (Mouse) 
2023-02-08 | PXD039050 | Pride
Mathematical modeling Adaptive immunity Sars-cov-2 Bmal1 Hepatitis a Circadian rhythm Vaccination Leukocyte trafficking 
UnknownEffect of Convalescent Plasma on Organ Support-Free Days in Critically Ill Patients With COVID-19: A Randomized Clinical Trial.
Not available
S-EPMC8491132 | biostudies-literature
UnknownConvalescent plasma in patients admitted to hospital with COVID-19 (RECOVERY): a randomised controlled, open-label, platform trial.
Not available
S-EPMC8121538 | biostudies-literature
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