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TranscriptomicsTranscription profiling of S. cerevisiae TPP 2-oxo acid decarboxylases
The irreversible decarboxylation step, which commits 2-oxo acids to the Ehrlich pathway, was initially attributed to pyruvate decarboxylase. However, the yeast genome was shown to harbour no fewer than 5 genes that show sequence similarity with thiamine-diphosphate dependent decarboxylase genes. Thr...
ORGANISM(S): Saccharomyces cerevisiae 
2008-06-16 | E-GEOD-9590 | biostudies-arrayexpress
TranscriptomicsDeletion of the Saccharomyces cerevisiae ARO8 gene, encoding an aromatic amino acid transaminase, enhances phenylethanol production from glucose
Its characteristic rose-like aroma makes phenylethanol a popular ingredient in foods, beverages and cosmetics. Microbial production of phenylethanol currently relies on whole-cell bioconversion of phenylalanine with yeasts that harbor an Ehrlich pathway for phenylalanine catabolism. Complete biosynt...
ORGANISM(S): Saccharomyces cerevisiae 
2014-03-19 | E-GEOD-52256 | biostudies-arrayexpress
TranscriptomicsResolving phenylalanine metabolism sheds light on natural synthesis of benzylpenicillin in Penicillium chrysogenum
Industrial production of penicillin G by Penicillium chrysogenum requires medium supplementation with the side chain precursor phenylacetate. However, P.chrysogenum grown in presence of phenylalanine as sole nitrogen source formed detectable extracellular amounts of phenylacetate and penicillin G. T...
ORGANISM(S): Penicillium chrysogenum 
2011-11-05 | E-GEOD-32097 | biostudies-arrayexpress
TranscriptomicsOrigin-dependent neural cell identities in differentiated human iPS cells in vitro and after transplantation into the rodent brain
The differentiation capability of induced pluripotent stem cells (iPSCs) towards certain cell types for disease modelling and drug screening assays might be influenced by their somatic cell of origin. Here, we have compared the neural induction of human iPSCs generated from either fetal neural stem ...
ORGANISM(S): Homo sapiens 
2014-09-12 | E-GEOD-55107 | biostudies-arrayexpress
UnknownProminent mediatory role of gut microbiome in the effect of lifestyle on host metabolic phenotypes.
Not available
S-EPMC12795280 | biostudies-literature
UnknownGrowth differences between North American and European children at risk for type 1 diabetes.
Not available
S-EPMC3335929 | biostudies-literature
UnknownHydrolyzed infant formula and early β-cell autoimmunity: a randomized clinical trial.
Not available
S-EPMC4225544 | biostudies-literature
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