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MetabolomicsP53 dependent hypusination of eIF5A affect mitochondrial translation and senescence immune surveillance
Cellular senescence is characterized by a permanent growth arrest and is associated with tissue aging and cancer. Senescent cells secrete a number of different cytokines referred to as the senescence-associated secretory phenotype (SASP), which impacts the surrounding tissue and immune response. Her...
2024-08-14 | MTBLS10690 | MetaboLights
MetabolomicsHypusination Orchestrates the Antimicrobial Response of Macrophages
Innate responses of myeloid cells defend against pathogenic bacteria via inducible effectors. Deoxyhypusine synthase (DHPS) catalyzes the transfer of the N-moiety of spermidine to the lysine-50 residue of eukaryotic translation initiation factor 5A (EIF5A) to form the amino acid hypusine. Hypusinate...
2021-04-06 | MTBLS607 | MetaboLights
ProteomicsBiochemical profile of the A.thaliana hypusination pathway
The eukaryotic translation elongation factor eIF5A is the only protein known to contain the unusual amino acid hypusine which is essential for its biological activity. This posttranslational modification is achieved by the sequential action of the enzymes deoxyhypusine synthase and deoxyhypusine hyd...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2016-07-09 | PXD000880 | Pride
Spermidine Eif5a Abscisic acid 2d-electrophoresis Hypusine 
ProteomicsInteraction of human eIF5A and DHS K329A variant studied by HDX-MS
Hypusination is a unique post-translational modification of the eukaryotic translation factor 5A (eIF5A) that is essential for overcoming ribosome stalling at polyproline sequence stretches. The initial step of hypusination, the formation of deoxyhypusine, is catalyzed by deoxyhypusine synthase (DHS...
ORGANISM(S): Homo sapiens (Human) Escherichia coli 
2023-05-10 | PXD040460 | Pride
Eif5a Hdx-ms Synapt-g2 si Dhs k329a variant 
GenomicsChemical genetic interaction linking eIF5A hypusination and mitochondrial integrity
Chemical genetic interaction linking eIF5A hypusination and mitochondrial integrity
PRJNA1106772 | ENA
ProteomicsEvaluation of N8-propargyl spermidine and spermine as substrates of deoxyhypusine synthase in the in vitro hypusination of eIF5A and RIPK1
eIF5A is a well-established protein substrate of deoxyhypusine synthase (DHS), which also requires spermidine as a small-molecule substrate. At the end of 2024, a publication claimed that RIPK1 is an additional DHS substrate and that N8-propargyl spermidine can also serve as a DHS substrate. To eval...
ORGANISM(S): Homo sapiens (Human) 
2026-03-13 | PXD071577 | Pride
N8-propargyl spermidine Dhs Eif5a Chemical probe Hypusination Deoxyhypusine synthase Ripk1 
GenomicsThe eIF5A hypusination inhibitor GC7 acts as a mitochondrial stress inducer
The eIF5A hypusination inhibitor GC7 acts as a mitochondrial stress inducer
PRJNA1021181 | ENA
GenomicsTargeting polyamine metabolism and eIF5A hypusination in pediatric acute myeloid leukemia
Targeting polyamine metabolism and eIF5A hypusination in pediatric acute myeloid leukemia
PRJNA1505732 | ENA
TranscriptomicsChemical genetic interaction linking eIF5A hypusination and mitochondrial integrity
The eukaryotic translation factor eIF5A plays an important role in translation elongation, especially across stretches of prolines and charged amino acids, and in translation termination. eIF5A undergoes hypusination, a post-translational modification unique to this protein, although the role of hyp...
ORGANISM(S): Homo sapiens 
2025-05-06 | GSE266331 | GEO
ProteomicsArginine metabolism regulates human erythroid differentiation through hypusination of eIF5A
Metabolic programs contribute to hematopoietic stem and progenitor cell (HSPC) fate, but it is not known whether the metabolic regulation of protein synthesis controls HSPC differentiation. Here, we show that SLC7A1/CAT1-dependent arginine uptake and its catabolism to the polyamine spermidine contro...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-01-25 | MSV000091139 | MassIVE
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