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ProteomicsKinetics of abacavir-induced remodelling of the Major Histocompatibility Complex class I peptide repertoire
Characterisation of the kinetics of abacavir-induced perturbation of the immunopeptidome of the Major Histocompatibility Complex (MHC) class I molecule HLA-B*57:01.
ORGANISM(S): Homo sapiens (Human) 
2021-05-11 | PXD024331 | Pride
Mhc i antigen presentation Drug hypersensitivity Peptide selection Abacavir T cells Human leukocyte antigen (hla) Immunopeptidome Tapasin 
ProteomicsEvidence of focusing the MHC class I immunopeptidome by tapasin
Investigation of the repertoire of peptide ligands of highly similar Major Histocompatibility complex (MHC) class I allomorphs differing in tapasin dependence; HLA-B*44:02 (tapasin dependent), HLA-B*44:05 (tapasin independent) and HLA-B*44:05 W147A mutant (tapasin dependent).
ORGANISM(S): Homo sapiens (Human) 
2025-06-02 | PXD054743 | Pride
Hla Tapasin Immunopeptidomics 
MetabolomicsFecal microbiota transplantation plus anti-PD-1 immunotherapy in advanced melanoma: a phase I trial

Fecal microbiota transplantation (FMT) represents a potential strategy to overcome resistance to immune checkpoint inhibitors in patients with refractory melanoma; however, the role of FMT in first-line treatment settings has not been evaluated. We conducted a multicenter phase I trial combining ...

2025-02-27 | MTBLS711 | MetaboLights
UnknownEffect of <i>Lactobacillus plantarum</i> 1243 fermentation on quality properties and metabolome of <i>Aronia melanocarpa</i> (Michx<i>.</i>) elliott juice.
Not available
S-EPMC12266521 | biostudies-literature
ProteomicsPassage of transmissible cancers in the Tasmanian devil is due to a dominant, shared peptide motif and a limited repertoire of MHC-I allotypes
Transmissible cancers are spread via the passage of malignant cells. The survival of the Tasmanian devil, the largest marsupial carnivore, is threatened by two independent transmissible cancers, devil facial tumour (DFT) 1 and devil facial tumour 2 (DFT2). To aid the development of a peptide vaccine...
ORGANISM(S): Sarcophilus harrisii 
2021-02-08 | PXD020614 | Pride
Contagious cancer Mhc Marsupial Transmissible cancer Tasmanian devil Immunopeptidome 
UnknownNatural Bioactive Substances in Fruits of Aronia melanocarpa (Michx.) Elliott Exposed to Combined Light-Type, Chitosan Oligosaccharide, and Spent Mushroom Residue Treatments.
Not available
S-EPMC9919629 | biostudies-literature
ProteomicsIdentification of neoantigens in oesophageal adenocarcinoma
We present data from tissues of seven oesophageal adenocarcinomas of CD4 and CD8 T cell epitopes eluted from the cell surface using mass spectrometry (immunopeptidomics) of presented HLA bound peptides.This dataset forms part of the publication:Nicholas, B., Bailey, A., McCann, K.J., Wood, O., Walke...
ORGANISM(S): Homo sapiens (Human) 
2022-09-27 | PXD031108 | Pride
Human Oesophageal adenocarcinoma Immunopeptidome Hla 
UnknownReactivity of canonical bacterial cytochrome <i>c</i> peroxidases: insights into the electronic structure of compound I.
Not available
S-EPMC11892367 | biostudies-literature
GenomicsGlobal epigenomic analysis of primary human pancreatic islets provides insights into type 2 diabetes susceptibility loci
Identifying cis-regulatory elements is important to understand how human pancreatic islets modulate gene expression in physiologic or pathophysiologic (e.g., diabetic) conditions. We conducted genome-wide analysis of DNase I hypersensitive sites, histone H3 lysine methylation marks (K4me1, K4me3, K7...
ORGANISM(S): Homo sapiens 
2010-11-02 | E-GEOD-23784 | biostudies-arrayexpress
UnknownCD8+ T-cell cross-competition is governed by peptide-MHC class I stability.
Not available
S-EPMC3744744 | biostudies-literature
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