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TranscriptomicscaArray_golub-00460: Prediction of central nervous system embryonal tumour outcome based on gene expression
Embryonal tumours of the central nervous system (CNS) represent a heterogeneous group of tumours about which little is known biologically, and whose diagnosis, on the basis of morphologic appearance alone, is controversial. Medulloblastomas, for example, are the most common malignant brain tumour of...
ORGANISM(S): Homo sapiens 
2015-05-16 | E-GEOD-68956 | biostudies-arrayexpress
ProteomicsIntegrated proteomics spotlight the proteasome as a pervasive therapeutic vulnerability in Embryonal Tumors with Multilayered Rosettes (ETMR)
Embryonal tumors with multilayered rosettes (ETMR) are rare malignant embryonal brain tumors. The prognosis of ETMR is poor and novel therapeutic approaches are desperately needed. Comprehension of ETMR tumor biology is based on only few previous molecular studies, which mainly relied on the analyse...
ORGANISM(S): Homo sapiens (Human) 
2024-01-08 | PXD045268 | Pride
Transcriptome Multiomics Embryonal tumor with multilayered rosettes Mass spectrometry 850k Methylome Etmr Embryonal brain tumor Lin28a Dna methylation Proteome 
TranscriptomicsTranscription profiling by array of human tumor cells with stem-like properties isolated from pediatric brain tumors
Background
Primitive brain tumors are the first cause of cancer-related death in children. Tumor cells with stem-like properties (TSCs), thought to account for tumorigenesis and therapeutic resistance, have been isolated from high-grade gliomas in adults. Whether TSCs are a common component of pe...
ORGANISM(S): Homo sapiens 
2011-09-07 | E-MEXP-2910 | biostudies-arrayexpress
TranscriptomicsExpression data from human brain tumors and human normal brain
The characteristics of immune cells infiltrating pediatric brain tumors is largely unexplored. A better understanding of these characteristics will provide a foundation for development of immunotherapy for pediatric brain tumors. Gene expression profiles were used to identify immune marker gene that...
ORGANISM(S): Homo sapiens 
2013-08-25 | E-GEOD-50161 | biostudies-arrayexpress
TranscriptomicsComparative genomic hybridization by array of human tumor cells with stem-like properties isolated from pediatric brain tumors
Background
Primitive brain tumors are the first cause of cancer-related death in children. Tumor cells with stem-like properties (TSCs), thought to account for tumorigenesis and therapeutic resistance, have been isolated from high-grade gliomas in adults. Whether TSCs are a common component of pe...
ORGANISM(S): Homo sapiens 
2011-09-07 | E-MEXP-2909 | biostudies-arrayexpress
GenomicsIn Vitro Modeling of and Automated Drug Screening in Embryonal Brain Tumors Using Tumor-Brain Organoids
In Vitro Modeling of and Automated Drug Screening in Embryonal Brain Tumors Using Tumor-Brain Organoids
PRJNA1291669 | ENA
GenomicsTranscriptome analysis of zebrafish wildtype adult brain and rb1-embryonal brain tumors by RNA-Seq
Transcriptome analysis of zebrafish wildtype adult brain and rb1-embryonal brain tumors by RNA-Seq
PRJNA475809 | ENA
UnknownFanconi anemia and biallelic BRCA2 mutation diagnosed in a young child with an embryonal CNS tumor.
Not available
S-EPMC3782106 | biostudies-literature
ProteomicsOverexpression of Lin28A in neural progenitor cells in vivo does not lead to brain tumor formation but results in reduced spine density
The RNA binding protein LIN28A is a stem- and progenitor marker and one of the factors necessary to induce pluripotent stem cells in vitro. LIN28A has been shown to promote the proliferative capacity of neural progenitor cells but its specific role during embryonal and postnatal brain development st...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-15 | PXD028044 | Pride
Lin28a Phosphopetide Etmr Dda dia lc-ms/ms 
TranscriptomicsIn Vitro Modeling of and Automated Drug Screening in Embryonal Brain Tumors Using Tumor-Brain Organoids
Embryonal brain tumors (EBTs), arising during early brain development, present significant challenges in understanding pathogenesis and developing of treatments. This study explores the efficacy of forebrain organoid (FBO) models in replicating the complexities of the EBT microenvironment. We establ...
ORGANISM(S): Homo sapiens 
2025-10-28 | GSE302654 | GEO
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