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TranscriptomicsGene Expression Analysis of Stage I Endometrial Cancers
Global gene expression patterns associated with early stage endometrial cancer have been reported, but changes in molecular expression associated with tumor grade, depth of myometrial invasion, and non-endometrioid histology have not been previously elucidated. Our group hypothesized there are uniq...
ORGANISM(S): Homo sapiens 
2011-12-13 | E-GEOD-17025 | biostudies-arrayexpress
ProteomicsProteomic and functional characterization of intra-tumor heterogeneity in human endometrial cancer.
Endometrial cancer (EC) is one of the most frequently diagnosed gynecological cancers worldwide, and its prevalence has increased by more than 50% over the last two decades. Despite the understanding of the major signaling pathways driving the growth and metastasis of EC cells, clinical trials targe...
ORGANISM(S): Homo sapiens (Human) 
2022-10-14 | PXD031784 | Pride
Endometrial cancer 
ProteomicsThe tumour-derived extracellular vesicle proteome varies by endometrial cancer histology and is confounded by an obesogenic environment
Endometrial cancer is the most prevalent gynaecological cancer globally. Its association with obesity and metabolic diseases is a key aetiology, increasingly among younger females. Early diagnosis and improved treatment decisions are crucial for these individuals which could be fulfilled by the disc...
ORGANISM(S): Homo sapiens (Human) 
2024-09-24 | PXD045074 | Pride
Swath Biomarkers Extracellular vesicles Endometrial cancer Secretome 
ProteomicsRole of prorenin receptor (P)RR in endometrial cancer cell growth
Endometrial cancer is the most commonly diagnosed gynecologic malignancy in women after breast, lung and colorectal cancer. Despite numerous scientific advances, the incidence and mortality rate of endometrial cancer is on the rise. Considerable research effort has therefore been placed on understan...
ORGANISM(S): Homo sapiens (Human) 
2022-04-23 | PXD023042 | Pride
Quantitative proteomics Endometrial epithelial cancer cell Cellular proliferation Tandem mass tags An3ca and hec-1a Atp6ap2 (p)rr Ishikawa Cellular viability 
ProteomicsProteomic profiling of tissue and plasma from mares with endometrial fibrosis
Endometrial fibrosis causes subfertility in mares, and is characterized by excessive deposition of extracellular matrix. It is diagnosed by a histopathologic evaluation of a biopsy, but the prognostic value of a single biopsy is limited, and a better understanding of the pathogenesis is needed. To g...
ORGANISM(S): Equus caballus (Horse) 
2026-01-19 | PXD056558 | Pride
Endometrial proteome Fibrotic endometrial degeneration Data independent acquisition mass spectrometry Equine Reproduction 
ProteomicsKinome Profiling of Primary Endometrial Tumors Using Multiplexed Inhibitor Beads and Mass Spectrometry Identifies SRPK1 As A Candidate Therapeutic Target
Protein kinases (collectively termed the kinome) represent one of the most tractable drug targets in the pursuit of new and effective cancer treatments. However, less than 20% of the kinome is currently being explored as primary targets for cancer therapy, leaving the majority of the kinome untarget...
ORGANISM(S): Homo sapiens (Human) 
2020-09-30 | PXD020357 | Pride
Endometrial Srpk1 
ProteomicsChanges in proteomics of endometrial tissue during secretion of polycystic ovary syndrome may affect endometrial receptivity
Polycystic ovary syndrome (PCOS) is one of the most common endocrinopathies among fertile women. PCOS patients have been confirmed to be accompanied by an increased risk of pregnancy complication, and the exact cause is still unclear. Many factors may cause this situation, and impaired endometrial r...
ORGANISM(S): Homo sapiens (Human) 
2022-06-09 | PXD024735 | Pride
Endometrium Proteomics. Endometrial receptivity Pcos 
ProteomicsEndometrial extracellular vesicle decidualization
Proper decidualization is vital in preparation for a potential embryo receptivity, placentation, menstrual health and subsequent endometrial regeneration. Given the importance of extracellular vesicles (EVs) in intercellular communication, and recently in embryo implantation and indicators of menstr...
ORGANISM(S): Homo sapiens (Human) 
2021-11-17 | PXD026342 | Pride
Exosomes Endometrial Extracellular vesicles Decidualization 
ProteomicsUncovering biological heterogeneity in endometrial carcinoma molecular subtypes by proteomic analysis
While endometrial cancer (EC) has an overall favorable prognosis, some patients do poorly and may benefit from refinements of current classification systems. Molecular classification stratifies ECs into four prognostic groups: POLEmut, MMRd (mismatch repair deficient), p53abn, and NSMP (no specific ...
ORGANISM(S): Homo sapiens (Human) 
2025-10-06 | PXD057700 | Pride
Ffpe Endometrial carcinoma Tmt 
ProteomicsA Proteogenomic View of Synchronous Endometrioid Endometrial and Ovarian Cancer
Purpose: Increasing genomics-based evidence suggests that synchronous endometrial and ovarian cancer (SEOC) represents clonally related primary and metastatic tumors. A systematic analysis of the global protein landscape of SEOCs, heretofore lacking, could reveal functional and disease-specific cons...
ORGANISM(S): Homo sapiens (Human) 
2025-03-11 | PXD059172 | Pride
Ovarian cancer Proteomics Endometrial cancer Synchronous cancer 
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