Sort   by:  
 Page size 
GenomicsImpaired endosomal recycling of signaling receptors activates an extracellular UPR
Impaired endosomal recycling of signaling receptors activates an extracellular UPR
PRJNA1475055 | ENA
GenomicsThe Alzheimer’s gene SORL1 is a key regulator of endosomal recycling in human neurons
The Alzheimer’s gene SORL1 is a key regulator of endosomal recycling in human neurons
PRJNA749578 | ENA
ProteomicsUSP32 regulates late endosomal transport and recycling through deubiquitylation of Rab7
The endosomal system is a highly dynamic multifunctional organelle, whose complexity is regulated in part by reversible ubiquitylation. Despite the wide-ranging influence of ubiquitin in endosomal processes, relatively few enzymes utilizing ubiquitin have been described to control endosome integrity...
ORGANISM(S): Homo sapiens (Human) 
2019-03-20 | PXD011899 | Pride
Endosomal trafficking Ubiquitin specific protease Ubiquitin Usp32 Rab gtpase 
TranscriptomicsThe Alzheimer’s gene SORL1 is a key regulator of endosomal recycling in human neurons
Loss of the Sortilin-related receptor 1 (SORL1) gene seems to act as a causal event for Alzheimer’s disease (AD). Recent studies have established that loss of SORL1, as well as mutations in autosomal dominant AD genes APP and PSEN1/2, pathogenically converge by swelling early endosomes, AD’s cytopat...
ORGANISM(S): Homo sapiens 
2022-03-01 | GSE180793 | GEO
ProteomicsFER drives tumor progression cues of invasive breast cancer cells through kinase-dependent control of proliferation and endosomal recycling
Triple-Negative Breast Cancer (TNBC) is a poorly targetable cancer subtype that exhibits a high metastatic potential. To develop new intervention strategies, it is crucial to understand the mechanisms governing migratory and invasive features of TNBC cells. Previously it was shown that high expressi...
ORGANISM(S): Homo sapiens (Human) 
2022-04-15 | PXD021307 | Pride
Analogue-sensitive Cell invasion Endosomal recycling. Breast cancer Fer tyrosine kinase Proliferation 
TranscriptomicsImpaired endosomal recycling of signaling receptors activates an extracellular UPR
Mitochondrial dysfunction and extracellular protein aggregation occur in neurodegenerative diseases such as Alzheimer’s disease (AD). However, it remains unclear if these processes are functionally linked. Here, we identify a signaling pathway that is activated upon accumulation of aggregation-prone...
ORGANISM(S): Homo sapiens 
2026-08-31 | GSE334451 | GEO
TranscriptomicsPresenilins mediate endosomal recycling via ARF6 to maintain proper lysosomal clearance
Autophagic and endosomal dysfunctions are prominently observed at preclinical stages of Alzheimer's disease (AD) as well as in presenilin (PSEN) 1-deficient mice and neurons. In the latter, the defects relate to the γ-secretase-independent role of PSEN in lysosomal fusion and organelle turnover. Whi...
ORGANISM(S): Mus musculus 
2017-12-15 | GSE44454 | GEO
ProteomicsRetriever is a multiprotein complex for retromer-independent endosomal cargo recycling
Following endocytosis into the endosomal network, integral membrane proteins undergo sorting for lysosomal degradation or are retrieved and recycled back to the cell surface. Here we describe the discovery of an ancient and conserved multiprotein complex which orchestrates cargo retrieval and recycl...
ORGANISM(S): Homo sapiens (Human) 
2018-01-15 | PXD007230 | Pride
Snx17 Retriever Retromer 
ProteomicsMolecular identification of a BAR domain-containing coat complex for endosomal recycling of transmembrane proteins
Protein trafficking requires coat complexes that couple recognition of sorting motifs in transmembrane cargos with biogenesis of transport carriers. The mechanisms of cargo transport through the endosomal network are poorly understood. Here, we identify a sorting motif for endosomal recycling of car...
ORGANISM(S): Homo sapiens (Human) 
2021-05-28 | PXD014927 | Pride
Snx-bars Endosomes Transmembrane proteins Endocytosis Ci-mpr 
TranscriptomicsImpaired endosomal recycling in proximal tubules is mechanistically linked to proteinuria
Through substitution mapping studies, we previously identified that a <330kb region from a rat strain with no renal pathology (the Lewis rat), which when introgressed onto the genetic background of a rat with renal disease (the Dahl Salt-sensitive (S) rat), caused an increase rather than the expecte...
ORGANISM(S): Rattus norvegicus 
2011-12-17 | E-GEOD-30770 | biostudies-arrayexpress
Sort   by:  
 Page size