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ProteomicsFunction of ERphagy receptors is regulated via phosphorylation-dependent ubiquitination pathways
Selective autophagy of the ER (ERphagy) is an important regulator of ER remodeling and critical to maintain cellular homeostasis upon environmental changes. ERphagy receptors link the ER with autophagic membrane thus regulating ERphagy flux. We recently showed that members of the FAM134 family play ...
ORGANISM(S): Homo sapiens (Human) 
2022-08-17 | PXD036103 | Pride
Ck2 Er homeostasis Lysosomal degradation Er remodeling Er fragmentation Chek1 Atr Selective autophagy Atm Stress response Ubiquitination Fam134b Fam134c Endoplasmic reticulum Mtor 
UnknownMicrotubule-associated protein 1 light chain 3 (LC3) interacts with Bnip3 protein to selectively remove endoplasmic reticulum and mitochondria via autophagy.
Not available
S-EPMC3365942 | biostudies-literature
UnknownAutophagy in Crohn's Disease: Converging on Dysfunctional Innate Immunity.
Not available
S-EPMC10341259 | biostudies-literature
UnknownHigh content screen for identifying small-molecule LC3B-localization modulators in a renal cancer cell line.
Not available
S-EPMC6018519 | biostudies-literature
UnknownAutophagy controls Wolbachia infection upon bacterial damage and in aging Drosophila.
Not available
S-EPMC9589277 | biostudies-literature
UnknownNon-small cell lung cancers (NSCLCs) oncolysis using coxsackievirus B5 and synergistic DNA-damage response inhibitors.
Not available
S-EPMC10518312 | biostudies-literature
UnknownNuclear fragile X mental retardation-interacting protein 1-mediated ribophagy protects T lymphocytes against apoptosis in sepsis
Not available
S-EPMC9976742 | biostudies-literature
ProteomicsMiT/TFE factors control ER-phagy via transcriptional regulation of FAM134B
Lysosomal degradation of the endoplasmic reticulum (ER) via autophagy (ER-phagy) is emerging as a critical regulator of ER homeostasis and function1. The selective incorporation of ER fragments into nascent autophagosomes is facilitated by ER resident proteins, ER-phagy receptors, that bind the auto...
ORGANISM(S): Rattus norvegicus (Rat) 
2020-07-15 | PXD015130 | Pride
Erphagy secretome 
ProteomicsER-phagy regulates ER dynamics during myogenesis
Endoplasmic reticulum (ER) plasticity and ER-phagy are intertwined processes essential for maintaining ER dynamics. We investigated the interplay between two isoforms of the ER-phagy receptor FAM134B in regulating ER remodeling in differentiating myoblasts. During myogenesis, the canonical FAM134B1 ...
ORGANISM(S): Homo sapiens (Human) 
2024-12-27 | PXD053361 | Pride
Fam134b Autophagy Erphagy 
ProteomicsER-phagy regulates ER dynamics during myogenesis (1)
Proteomic profile of C2C12 myoblasts and differentiated myotubes
ORGANISM(S): Mus musculus (Mouse) 
2024-12-27 | PXD050867 | Pride
Erphagy Myogenesis Autophagy 
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