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ProteomicsQuantitative Proteomics of Dorsolateral Prefrontal Cortex
Autism spectrum disorder (ASD) is a severe neurodevelopmental disorder with a rising prevalence and genetic and environmental etiologies. Symptoms include deficits in social communication, repetitive patterns of behavior, and cognitive impairment. Neuroanatomic and biochemical investigations involve...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD048017 | Pride
Autism  brodmann area 9  childhood  proteomics 
ProteomicsImpaired aggrephagy,abnormal vesicular trafficking and cellular stress, lead to protein aggregation,neurodegeneration and synaptic dysfunction in cerebellar vermis of children and adults with idiopathic autism
Autism spectrum disorder (ASD) is a debilitating neurodevelopmental disorder with genetic and environmental etiologies involving several brain areas exhibiting abnormalities of cognition and social behavior. Previous work showed involvement of synaptic abnormalities in dorsolateral prefrontal cortex...
ORGANISM(S): Homo sapiens (Human) 
2025-08-25 | PXD061746 | Pride
Lc-ms/ms Proteomics Vermis Vesicular transport Human Cerebellum Autism Protein misfolding Asd Proteostasis Neurodegeneration 
ProteomicsQuantitative Proteomics of Intracellular Traffic in Down Syndrome Brain
The effect of fluoxetine on the proteome of synaptic fractions of cerebral cortex tissue of male Ts65Dn mice was compared to the effect in euploid mice.
ORGANISM(S): Mus musculus (Mouse) 
2024-05-21 | PXD048722 | Pride
Down syndrome Mose Fluoxetine Cerebral cortex 
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