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TranscriptomicsDifferential mRNA accumulation in Arabidopsis lacking the exoribonuclease XRN4 indicates a preference of the enzyme for specific mRNA sequences and functional categories
One of the major players controlling RNA decay is the cytoplasmic 5’ to 3’ exoribonuclease, which is conserved among eukaryotic organisms. In Arabidopsis, the 5’ to 3’ exoribonuclease XRN4 is involved in disease resistance, the response to ethylene, RNAi and miRNA-mediated RNA decay. Curiously, XRN4...
ORGANISM(S): Arabidopsis thaliana 
2011-01-14 | E-GEOD-23027 | biostudies-arrayexpress
TranscriptomicsDifference in gene expression between WT (Col-0) and atxrn4-3 mutant under non-stress and heat stress condition
Arabidopsis 5’-3’ exoribonuclease, AtXRN4, a homolog of yeast Xrn1p, functions in degradation of uncapped RNAs after de-capping step. While Xrn1p-dependent on plant XRN4’s targets for degradation is still limited. For understanding biological function of AtXRN4, we tested survivability of atxrn4 mut...
ORGANISM(S): Arabidopsis thaliana 
2015-07-14 | E-GEOD-66369 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Arabidopsis Col-0, ein2-5 and ein5-1 ETHYLENE-INSENSITIVE5 encodes a 5 to 3 exoribonuclease required for posttranscriptional regulation
Ethylene is a gaseous plant growth regulator that controls a multitude of developmental and stress responses. Recently, the levels of Arabidopsis EIN3 protein, a key transcription factor mediating ethylene-regulated gene expression, have been demonstrated to increase in response to the presence of e...
ORGANISM(S): Arabidopsis thaliana 
2008-06-13 | E-GEOD-5174 | biostudies-arrayexpress
TranscriptomicsThe effect of Dis3 knockdown on miRNA expression in Drosophila wing imaginal discs.
We investigated the effect on miRNA expression in Drosophila melanogaster wing imaginal discs following the knockdown of the 3'-5' exoribonuclease Dis3.
ORGANISM(S): Drosophila melanogaster 
2015-06-01 | E-MTAB-3569 | biostudies-arrayexpress
GenomicsTick-borne flavivirus exoribonuclease-resistant RNAs contain a double loop structure
Tick-borne flavivirus exoribonuclease-resistant RNAs contain a double loop structure
PRJNA1124586 | ENA
TranscriptomicsA conserved factor Dhp1/Rat1/Xrn2 triggers premature transcription termination and nucleates heterochromatin to promote gene silencing [sRNA-seq]
Co-transcriptional RNA processing and surveillance factors mediate heterochromatin formation in fission yeast. In addition to RNAi, RNA elimination machinery including MTREC (Mtl1-Red1 core) and the exosome are involved in facultative heterochromatin assembly, however, the exact mechanisms remain un...
ORGANISM(S): Schizosaccharomyces pombe 
2016-01-05 | E-GEOD-74739 | biostudies-arrayexpress
TranscriptomicsGenome-wide identification of non-coding RNAs targeted by XRN exoribonucleases in collaboration with FRY1 using RNA-Seq in Arabidopsis thaliana.
We report new insight of non-coding RNA degradation mediated by XRN exoribonucleases and FRY1 in Arabidopsis thaliana. We suggest that XRN3, in combination with FRY1, is required to prevent the accumulation of 3’ extensions that arise from thousands of mRNA and miRNA precursor transcripts. Examinati...
ORGANISM(S): Arabidopsis thaliana 
2012-05-02 | E-GEOD-34654 | biostudies-arrayexpress
ProteomicsMUT-7 exoribonuclease activity and localisation are mediated by an ancient domain
The MUT-7 family of 3’-5’ exoribonucleases is evolutionarily conserved across the animal kingdom and plays essential roles in small RNA production in the germline. Most MUT-7 homologs carry a C-terminal domain of unknown function named MUT7 C appended to the exoribonuclease domain. Our analysis show...
ORGANISM(S): Escherichia coli Caenorhabditis elegans 
2024-10-17 | PXD048205 | Pride
Mut7-c Mut-7 Rde-2 Mut-8 Mutator complex 
TranscriptomicsGene expression profiling of constitutively competent comR and proQ mutants and RNase R (rnr) mutant of L. pneumophila
Bacterial competence is a genetically programmed process that is triggered as a response to environmental stimuli. DNA uptake from the extracellular milieu by competence requires the expression of a complex machinery composed of a competence pseudopilus and a DNA translocase. In L. pneumophila, it ...
ORGANISM(S): Legionella pneumophila 
2010-05-20 | E-GEOD-12796 | biostudies-arrayexpress
TranscriptomicsExpression data in Arabidopsis fry1-6, xrn2-4, xrn3-3 and xrn4-6 mutants.
We applied the tiling arrays to study the Arabidopsis whole-genome transcriptome in Arabidopsis fry1-6, xrn2-4, xrn3-3 and xrn4-6 mutants. The total RNA was prepared from 15-day-old Arabidopsis plants grown on the agar plates and used for the microarray hybridization. Three replicative hybridizati...
ORGANISM(S): Arabidopsis thaliana 
2012-05-02 | E-GEOD-32977 | biostudies-arrayexpress
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