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ProteomicsCD47 interactions with exportin-1 regulate targeting of m7G-capped RNAs to extracellular vesicles
CD47 is a marker of self and a signaling receptor for thrombospondin-1 that is also a membrane component of extracellular vesicles (EVs) released by various cell types. Previous studies identified CD47-dependent functional effects of EVs on target cells, mediated by delivery of their RNA contents, a...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-03-01 | MSV000086969 | MassIVE
GenomicsCancer-associated exportin-6 upregulation inhibits the transcriptional repressive and anticancer effects of nuclear profilin-1
Cancer-associated exportin-6 upregulation inhibits the transcriptional repressive and anticancer effects of nuclear profilin-1
PRJNA603508 | ENA
ProteomicsExportin 1 modulates lifespan by regulating nucleolar dynamics via the autophagy protein LGG-1/GABARAP
Altered nucleolar and ribosomal dynamics are key hallmarks of aging, but their regulation remains unclear. Building on the knowledge that the conserved nuclear export receptor Exportin 1 (XPO-1/XPO1) modulates proteostasis and lifespan, we systematically analyzed the impact of nuclear export on prot...
ORGANISM(S): Caenorhabditis elegans 
2026-02-23 | PXD027230 | Pride
Autophagy Proteomics Aging Proteostasis 
GenomicsExportin 1 inhibition prevents neuroendocrine transformation through SOX2 downregulation in lung and prostate cancers [ATAC-seq]
In lung and prostate adenocarcinomas, neuroendocrine (NE) transformation to an aggressive derivative resembling small cell lung cancer (SCLC) is associated with poor prognosis. We previously described dependency of SCLC on the nuclear transporter exportin 1. Here we explored the role of exportin 1 i...
ORGANISM(S): Homo sapiens 
2023-07-12 | GSE237071 | GEO
TranscriptomicsExportin 1 inhibition prevents neuroendocrine transformation through SOX2 downregulation in lung and prostate cancers [RNA-seq]
In lung and prostate adenocarcinomas, neuroendocrine (NE) transformation to an aggressive derivative resembling small cell lung cancer (SCLC) is associated with poor prognosis. We previously described dependency of SCLC on the nuclear transporter exportin 1. Here we explored the role of exportin 1 i...
ORGANISM(S): Homo sapiens 
2023-07-12 | GSE237072 | GEO
GenomicsExportin 1 inhibition prevents neuroendocrine transformation through SOX2 downregulation in lung and prostate cancers [RNA-seq]
Exportin 1 inhibition prevents neuroendocrine transformation through SOX2 downregulation in lung and prostate cancers [RNA-seq]
PRJNA993666 | ENA
GenomicsExportin 1 inhibition prevents neuroendocrine transformation through SOX2 downregulation in lung and prostate cancers [ATAC-seq]
Exportin 1 inhibition prevents neuroendocrine transformation through SOX2 downregulation in lung and prostate cancers [ATAC-seq]
PRJNA993665 | ENA
TranscriptomicsCancer-associated exportin-6 upregulation inhibits the transcriptional repressive and anticancer effects of nuclear profilin-1
Aberrant expression of nuclear transporters and altered subcellular localization of their cargo proteins are increasingly recognized as drivers and therapeutic targets of cancer. Here, we report that exportin-6, a nuclear exporter specific for actin/profilin-1, is upregulated in a broad range of can...
ORGANISM(S): Homo sapiens 
2021-04-07 | GSE144372 | GEO
UnknownAn Exportin-1-dependent microRNA biogenesis pathway during human cell quiescence.
Not available
S-EPMC5488920 | biostudies-literature
ProteomicsXpo7 is a broad-spectrum exportin and a nuclear import receptor
Cargo molecules which exceed the passive diffusion limit of ~5nm require active translocation to cross the nuclear pore complex (NPC). Such a facilitated transport is achieved by specialized nuclear transport receptors (NTRs), which are classified according to their shuttling direction. Exportins bi...
ORGANISM(S): Mus musculus (Mouse) 
2018-05-07 | PXD008746 | Pride
Lc-msms Importin Exportin Nanobodies Npcs Erythropoiesis Rangtpase Mouse 
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