Sort   by:  
 Page size 
TranscriptomicsInhibitor of NFκB ζ (IκBζ) is a transcriptional key regulator of monocyte chemoattractant protein-1 (MCP-1/CCL2)
Monocyte chemoattractant protein 1 (MCP-1/CCL2) is critically involved in directing the migration of blood monocytes to sites of inflammation. Consequently, excessive MCP-1 secretion has been linked to many (auto)inflammatory diseases, whereas a lack of expression severely impairs immune responsiven...
ORGANISM(S): Mus musculus 
2013-04-09 | E-GEOD-43075 | biostudies-arrayexpress
ProteomicsSame same but different – The global response of Escherichia coli to five different LpxC inhibitors
A promising but yet clinically unexploited antibiotic target in difficult-to-treat Gram-negative bacteria is LpxC, the key enzyme in the biosynthesis of lipopolysaccharides (LPS), which are the major constituents of the outer membrane. To gain insights into the mode of action of five different LpxC ...
ORGANISM(S): Escherichia coli 
2024-06-16 | PXD043195 | Pride
Lipopolysaccharide Lps Antibiotics Phospholipid Outer membrane Ftsh 
MetabolomicsIntegration of magnetic resonance imaging and protein and metabolite CSF measurements to enable early diagnosis of secondary progressive multiple sclerosis

Molecular networks in neurological diseases are complex. Despite this fact, contemporary biomarkers are in most cases interpreted in isolation, leading to a significant loss of information and power. We present an analytical approach to scrutinize and combine information from biomarkers originati...

2018-08-13 | MTBLS558 | MetaboLights
ProteomicsMultiomic profiling of medulloblastoma reveals subtype-specific targetable alterations at the proteome and N-glycan level
Medulloblastomas (MBs) are malignant pediatric brain tumors that are molecularly and clinically very heterogenous. To unravel phenotypically relevant MB subtypes, we compiled a harmonized proteome dataset of 167 MBs and integrated findings with DNA methylation and N-glycome data. Six proteome MB sub...
ORGANISM(S): Homo sapiens (Human) 
2024-06-05 | PXD039319 | Pride
Medulloblastoma subtypes Mass spectrometry 850k Tnc Multiomics Wnt Palmd N-glycan Tric/cct N-glycome Myc Harmonizr Dna methylation Shh Proteome 
ProteomicsProteome profiling of Rhodobacter capsulatus wild type and a ΔmodABC mutant in response to molybdenum
The diazotrophic bacterium Rhodobacter capsulatus is able to synthesize two nitrogenases, a molybdenum-dependent and an alternative Mo-free iron-only nitrogenase, enabling growth with molecular dinitrogen (N2) as sole nitrogen source. The Mo response of the wild type and a mutant lacking the high-af...
ORGANISM(S): Rhodobacter capsulatus (strain ATCC BAA-309 / NBRC 16581 / SB1003) 
2015-12-14 | PXD003123 | Pride
Rhodobacter capsulatus molybdenum lc-ms proteomics mse 
GenomicsNational Eye Institute Glaucoma Human Genetics Collaboration (NEIGHBOR) Consortium Glaucoma Genome-Wide Association Study

This is a case-control study of primary open angle glaucoma (POAG). POAG is an intraocular pressure (IOP) related progressive optic neuropathy that ultimately leads to blindness. For this study we have formed a collaborative consortium contributing 2170 POAG cases and 2347 controls with a unified...

phs000238.v1.p1 | EGA
UnknownProtecting stable biological nomenclatural systems enables universal communication: A collective international appeal.
Not available
S-EPMC11328142 | biostudies-literature
UnknownGenetic correlation between amyotrophic lateral sclerosis and schizophrenia.
Not available
S-EPMC5364411 | biostudies-literature
UnknownImmunomodulators for immunocompromised patients hospitalized for COVID-19: a meta-analysis of randomized controlled trials.
Not available
S-EPMC10867612 | biostudies-literature
UnknownGenetic influences on schizophrenia and subcortical brain volumes: large-scale proof of concept.
Not available
S-EPMC4852730 | biostudies-literature
Sort   by:  
 Page size