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Heme, an iron-containing prosthetic group found in many proteins, carries out diverse biological functions such as electron transfer, oxygen storage and enzymatic reactions. Hemin, the oxidised form of heme, is used to treat porphyria and also to activate heme-oxygenase (HO) which catalyses the rate...
ORGANISM(S): Mus musculus (Mouse) 
2023-07-20 | PXD036701 | Pride
Mesenchymal stromal stem cells (MSCs) gain increasing focus in the field of regenerative medicine due to their differentiational abilities into chondrocytes, adipocytes and osteoblastic cells. However, it is apparent that the transformation processes are extremely complex, cause cellular heterogenei...
ORGANISM(S): Homo sapiens (Human) 
2022-03-25 | PXD029900 | Pride
TDP-43 proteinopathy is a hallmark of neurodegenerative disorders such as amyotrophic lateral sclerosis and frontotemporal dementia where mislocalization of TDP-43 has been observed in neurons and glial cells. However, the role of TDP-43 in microglia and the consequences of its loss-of-function rema...
ORGANISM(S): Mus musculus (Mouse) 
2026-04-29 | PXD070157 | Pride
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