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Histone methyltransferases catalyze site-specific deposition of methyl groups, enabling recruitment of transcriptional regulators. In mammals, trimethylation of lysine 4 in histone H3, a modification localized at the transcription start sites of active genes, is catalyzed by six enzymes (SET1a and S...
ORGANISM(S): Mus musculus 
As shown by large-scale human genetic data, cancer mutations display strong tissue-selectivity, but how this selectivity arises remains unclear. Here, using experimental models, functional genomics and analysis of patient samples, we demonstrate that the lineage transcription factor paired box 8 ...
ORGANISM(S): Homo sapiens (Human) 
2022-03-14 | PXD029522 | Pride
This project identifies and quantitates Hydroxyapatite binding proteins (HAP) in plasma genotyped for complement factor H (CFH) polymorphism in late stage age-related macular degeneration (AMD) patients by sequential window acquisition of all theoretical mass spectra (SWATH). This study provides ins...
ORGANISM(S): Homo sapiens (Human) 
2018-03-28 | PXD007944 | Pride
Sca1+/cKit– hematopoietic BMCs of hosts bearing primary tumors promote the growth of distant tumors that form with a myofibroblast-rich, desmoplastic stroma. BMCs from old mice bearing primary tumors lack this ability Sca1+/cKit- BMCs were isolated from young and old mice bearing Matrigel control ...
ORGANISM(S): Mus musculus 
Beauchamp EM, Leventhal M, Bernard E, Hoppe ER, Todisco G, Creignou M, Galli A, Castellano CA, McConkey M, Tarun A, Wong W, Schenone M, Stanclift C, Tanenbaum B, Malolepsza E, Nilsson B, Bick AG, Weinstock JS, Miller M, Niroula A, Dunford A, Taylor-Weiner A, Wood T, Barbera A, Anand S, Psaty BM, Des...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-04-26 | MSV000087304 | MassIVE
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