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ProteomicsNovel protocol for spatial proteome analysis of formalin fixed paraffin embedded tissues
Novel In-insert FFPE proteomics combines single glass insert FFPE tissue processing with spatial quantitative data-independent mass spectrometry (DIA). In-insert proteomics represents a blueprint in spatial FFPE tissue subsection processing by completely omitting the robotic platform, desalting prio...
ORGANISM(S): Homo sapiens (Human) 
2024-04-19 | PXD037609 | Pride
Homo sapiens Breast tissue Cytoskeleton Prolactin induced protein Exploris 480 Glass insert Protein quantitation Spatial proteomics Ffpe tissue Hormonal regulation Data independent mass spectrometry 
ProteomicsNovel protocol for spatial proteome analysis of microdissected formalin-fixed paraffin-embedded tissues
Novel In-insert FFPE proteomics combines single glass insert FFPE tissue processing with spatial quantitative data-independent mass spectrometry (DIA). The method represents a potent protocol for spatial FFPE tissue subsection processing in combination with laser capture microdissection, achieving s...
ORGANISM(S): Homo sapiens (Human) 
2024-06-03 | PXD051706 | Pride
Human Limited proteomics Breast tissue Formalin-fixed paraffin-embedded tissue Mammary acini Exploris 480 Laser capture microdissection Spatial proteomics 
ProteomicsHuman colorectal cancer cell lines with manipulated AGR2 expression SWATH MS
SWATH MS analysis of colorectal adenocarcinoma derived paired cellular model, namely SW480 derived from a primary tumour and SW620 derived from the tumour´s lymph node metastasis. The whole proteome spectra were analysed to assess the changes caused by the manipulation of AGR2 expression. AGR2, a pr...
ORGANISM(S): Homo sapiens (Human) 
2025-04-23 | PXD053085 | Pride
Sw480 Colorectal adenocarcinoma Sw620 Agr2 Swath ms 
ProteomicsGenetic ablation of ifitm1 and ifitm3 attenuates IFN- mediated induction of ISG15 and MHC class I molecules
Interferon-induced transmembrane protein (IFITM1) plays a dual role in restriction of RNA viruses and in metastatic cancer cell growth. The signal transduction events that are orchestrated by IFITM1 are not well defined. We set out to identify IFITM1 interacting proteins to begin to define its mecha...
ORGANISM(S): Homo sapiens (Human) 
2020-05-26 | PXD007562 | Pride
Human Cancer Swath Silac Cell lines Ifn Lc-ms/ms 
ProteomicsRevealing Melanoma Cell Proteome Transformations with Silver Nanoparticles: An Innovative Comparative Study
Addressing the challenges of melanoma, including its aggressive nature and treatment resistance. This study explores the application of silver nanoparticles (AgNPs) synthesized via conventional and green methods. By examining proteomic changes in A375 melanoma cells, we identify key disruptions in c...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD058049 | Pride
Melanoma Silver nanoparticles (agnps) Dia ms Nanomedicine Swath ms Proteomics Green nanoparticles Anti-cancer 
ProteomicsQualitative and quantitative proteomic analysis of cancer-PD1 interactome in osteosarcoma cells
The PD-1 immune checkpoint is the target for cancer immunotherapy, which has recently revolutionized cancer treatment approaches. Interestingly, PD-1 is not only expressed by immune cells but also by cancer cells, however contradictory reports are available regarding its significance. The role and P...
ORGANISM(S): Homo sapiens (Human) 
2025-03-06 | PXD050950 | Pride
Cancer-intrinsic pd-1 Pd-1 Interactome Osteosarcoma 
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