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ProteomicsA core UPS molecular complement implicates unique endocytic compartments at the parasite-host interface in Giardia lamblia – native IP conditions
Affinity purification and mass spectrometry coupled to microscopy-based subcellular localization and signal correlation quantification techniques were employed to investigate protein complexes of eleven reported unconventionally-secreted putative and confirmed virulence factors of Giardia lamblia, a...
ORGANISM(S): Giardia intestinalis assemblage A 
2022-07-15 | PXD035190 | Pride
Giardia lamblia Virulence Unconventional protein secretion Peripheral endocytic compartments Interactome 
ProteomicsA core UPS molecular complement implicates unique endocytic compartments at the parasite-host interface in Giardia lamblia – crosslinking IP conditions
Affinity purification and mass spectrometry coupled to microscopy-based subcellular localization and signal correlation quantification techniques were employed to investigate protein complexes of eleven reported unconventionally-secreted putative and confirmed virulence factors of Giardia lamblia, a...
ORGANISM(S): Giardia intestinalis assemblage A 
2022-07-15 | PXD035195 | Pride
Giardia lamblia Virulence Unconventional protein secretion Peripheral endocytic compartments Interactome 
ProteomicsThe interactomes of GlFYVE PIP-binding protein in Giardia lamblia
We investigated the composition of the interactomes of 7 proteins in the parasitic protist Giardia lamblia, some of which were found to be associated to clathrin assemblies. This accession refers to GlFYVE.
ORGANISM(S): Giardia lamblia ATCC 50803 
2019-05-20 | PXD013897 | Pride
Lipid-binding Parasite Clathrin Pip Protist Immunoprecipitation Endocytosis 
ProteomicsThe interactomes of GlPXD2 and 4 PIP-binding proteins in Giardia lamblia
We investigated the composition of the interactomes of overall 7 proteins in the parasitic protist Giardia lamblia, some of which were found to be associated to clathrin assemblies. This accession refers to proteins GlPXD2 and 4
ORGANISM(S): Giardia lamblia ATCC 50803 
2019-05-20 | PXD013899 | Pride
Lipid-binding Parasite Clathrin Pip Protist Immunoprecipitation Endocytosis 
ProteomicsThe interactomes of GlPXD1, 3 and 6 PIP-binding proteins in Giardia lamblia
We investigated the composition of the interactomes of 7 proteins in the parasitic protist Giardia lamblia, some of which were found to be associated to clathrin assemblies. This accession refers to the first three namely GlPXD1, 3 and 6.
ORGANISM(S): Giardia lamblia ATCC 50803 
2019-05-20 | PXD013890 | Pride
Lipid-binding Parasite Clathrin Pip Protist Immunoprecipitation Endocytosis 
ProteomicsThe interactomes of GlNECAP PIP-binding proteins in Giardia lamblia
We investigated the composition of the interactomes of 7 proteins in the parasitic protist Giardia lamblia, some of which were found to be associated to clathrin assemblies. This accession refers GlNECAP.
ORGANISM(S): Giardia lamblia ATCC 50803 
2019-05-20 | PXD013896 | Pride
Lipid-binding Parasite Clathrin Pip Protist Immunoprecipitation Endocytosis 
ProteomicsSerial co-immunoprecipitation to expand the protein interactome of the outer mitosomal membrane in Giardia lamblia
Giardia lamblia's outer mitosomal membrane protein repertoire was investigated using a series of co-immunoprecipitations which led to the discovery of novel associated components. This was assembled into a Giardia mitosomal protein interactome which expands beyond the organelle, reaching out to othe...
ORGANISM(S): Giardia lamblia ATCC 50803 
2016-11-15 | PXD004583 | Pride
Crosslinking Protein discovery 
ProteomicsCo-immunoprecipitation of HA-tagged proteins in Giardia lamblia
Giardia lamblia's diverged endocytic system was investigated using co-immunoprecipitation of known and conserved endocytic factors which led to the discovery of novel associated components. This was assembled into an interactome of the endocytic pathway in this intestinal parasite.
ORGANISM(S): Giardia lamblia ATCC 50803 
2016-06-23 | PXD003718 | Pride
Co-immunoprecipitation  clathrin  endocytosis  giardia lamblia 
ProteomicsThe N’ terminus of Alpha-1 Giardin, a parasitic annexin orthologue, is essential for oligomerization and lipid-binding activity
We present a functional analysis of alpha-giardins (αGs), with a particular focus on α1-giardin (α1G), a leading vaccine candidate against giardiasis and a putative virulence-associated UPS substrate. We show that αGs localize to peripheral endocytic compartments (PECs), specialized endo-lysosomal o...
ORGANISM(S): Giardia intestinalis assemblage A 
2026-06-11 | PXD074377 | Pride
Lipid Molecular dynamics Annexin a5 Unconventional secretion Pip Oligomerization Endocytic compartments Membrane-binding Giardia lamblia Alpha-giardin 
UnknownUrinary Sodium-to-Potassium Ratio and Blood Pressure in CKD.
Not available
S-EPMC7403539 | biostudies-literature
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