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TranscriptomicsHippocampal expression data from FTY720- and vehicle-treated SCID mice following fear consolidation testing
FTY720/Fingolimod, an FDA-approved drug for treatment of multiple sclerosis, has beneficial effects in the CNS that are not yet well understood, independent of its effects on immune cell trafficking. Here we show that FTY720 enters the nucleus where it is phosphorylated by sphingosine kinase 2 (SphK...
ORGANISM(S): Mus musculus 
2014-05-12 | E-GEOD-57015 | biostudies-arrayexpress
TranscriptomicsGene expression induced by trace fear conditioning in murine hippocampus
Gene expression profiling following different learning paradigms may help in defining the moleular pathways of memory formation. In this study we analyzed the gene expression pattern of murine hippocampus at different time points (0.5 h, 2h, 6h) after trace fear conditioning. We compared trained mic...
ORGANISM(S): Mus musculus 
2010-05-27 | E-GEOD-16158 | biostudies-arrayexpress
ProteomicsSex differences in the role of protein degradation in the amygdala during fear memory formation
This project examined sex differences in the role of degradation-specific protein polyubiquitination in the amygdala during context fear memory formation in male and female rats.
ORGANISM(S): Rattus norvegicus (Rat) 
2021-09-28 | PXD027544 | Pride
Sex differences Consolidation Amygdala Memory Ubiquitin 
ProteomicsQuantitative proteomic analysis of mouse hippocampus in the context of fear memory
Quantitative proteomic analysis was used to identify the proteins associated with a formation of fear memory in mice. The proteins from the hippocampal region were isolated from three groups of trained aminals representing aquisition, consolidation and retrieval of a contextual fear conditioning. Th...
ORGANISM(S): Mus musculus (Mouse) 
2017-11-17 | PXD001639 | Pride
Contextual fear conditioning Fear memory Quantitative proteomic analysis Hippocampus 
ProteomicsThe role of linear ubiquitination in memory formation
This project examined the role of linear polyubiquitination in the amygdala during fear memory formation in male and female rats.
ORGANISM(S): Rattus norvegicus (Rat) 
2021-06-28 | PXD025483 | Pride
Sex differences Consolidation Amygdala Memory Ubiquitin 
TranscriptomicsEpigenetic priming of memory updating during reconsolidation to attenuate remote fear memories
Remembrances of traumata range among the most enduring forms of memories. Despite the elevated lifetime prevalence of anxiety disorders, effective strategies to attenuate long-term traumatic memories are scarce. The most efficacious treatments to diminish recent (i.e., day-old) traumata capitalize o...
ORGANISM(S): Mus musculus 
2014-01-04 | E-GEOD-53794 | biostudies-arrayexpress
TranscriptomicsMicroarray dataset of gene transcription in mouse microglia and peripheral monocytes in contextual fear conditioning
Using Illumina MouseWG-6v2 microarrays, we investigated the gene transcription changes in microglia and peripheral monocytes after contextual fear conditioning of C57BL/6J mice. Mice were trained with or without a single minimized footshock stimulation (0-s or 2-s, 0.4 mA) and re-exposed to the trai...
ORGANISM(S): Mus musculus 
2022-10-28 | E-MTAB-12361 | biostudies-arrayexpress
ProteomicsSex differences in the role of K48 polyubiquitination in indirectly acquired fear memories
This project examined sex differences in the role of K48 polyubiquitination in the amygdala during the indirect acquisition (observing another animal undergo fear conditioning) of an auditory fear memory formation in male and female rats.
ORGANISM(S): Rattus norvegicus (Rat) 
2024-12-02 | PXD041661 | Pride
Sex differences Consolidation Amygdala Memory Ubiquitin Ptsd K48 
ProteomicsSex differences in the role of protein sumoylation in the amygdala during fear memory formation
This project examined sex differences in the role of protein sumoylation in the amygdala during context fear memory formation in male and female rats.
ORGANISM(S): Rattus norvegicus (Rat) 
2022-05-27 | PXD029825 | Pride
Sex differences Sumoylation Consolidation Amygdala Memory 
ProteomicsSex differences in the role of K63 polyubiquitination in the amygdala during fear memory formation
This project examined sex differences in the role of K63 polyubiquitination in the amygdala during context fear memory formation in male and female rats.
ORGANISM(S): Rattus norvegicus (Rat) 
2023-05-18 | PXD036369 | Pride
Sex differences Consolidation Amygdala K63 Memory Ubiquitin 
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