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ProteomicsMudPIT analyses of whole cell extracts from Y1 murine adrenocortical carcinoma cell line stimulated with serum or FGF2
Fibroblast growth factor 2 (FGF2) is well known as a promoter of cell proliferation, however, in some cellular contexts, it can induce cell cycle arrest or cell death. In Y1 murine adrenocortical carcinoma cell line, FGF2 induces G0/G1 transition but delays S-phase progression and permanently block ...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2017-10-23 | MSV000081638 | MassIVE
ProteomicsA novel TTBK2 missense variant causes loss of function and impaired protein phosphorylation: implications for spinocerebellar ataxia type 11
Spinocerebellar ataxia type 11 (SCA11) is a rare form of autosomal dominant cerebellar ataxia, characterized by a relatively slow progression and normal life expectancy. However, it is a highly debilitating disorder. In 2007, SCA11 was genetically linked to TTBK2, which encodes tau tubulin kinase 2 ...
ORGANISM(S): Homo sapiens (Human) 
2025-12-22 | PXD056662 | Pride
Spinocerebellar ataxia type 11 (sca11)  tau-tubulin kinase 2 (ttbk2)  crispr/cas9  kinase activity  phosphoproteomics  cytoskeleton 
ProteomicsProteomics analysis of gastric cancer patients with diabetes mellitus
Proteomics is a powerful approach to study the molecular mechanisms of cancer. In this study, we aim to characterize the proteomic profile of gastric cancer (GC) in patients with diabetes mellitus (DM) type 2. Forty GC tissue samples including 19 cases from diabetic patients and 21 cases from indivi...
ORGANISM(S): Homo sapiens (Human) 
2021-01-22 | PXD022915 | Pride
Gastric cancer (gc)  diabetes mellitus (dm)  proteomics  label free quantification (lfq) 
ProteomicsGlycation modulates glutamatergic signaling and exacerbates Parkinson’s disease-like phenotypes
Alpha-synuclein (aSyn) is a central player in the pathogenesis of synucleinopathies due to its accumulation in typical protein aggregates in the brain. However, it is still unclear how it contributes to neurodegeneration. Type-2 diabetes mellitus is a risk factor for Parkinson’s disease (PD) ...
ORGANISM(S): Mus musculus (Mouse) 
2022-05-20 | PXD032832 | Pride
Brain Parkinson's disease Glycation 
TranscriptomicsIdentification of novel tissue-specific transcription arising from E-cadherin/CDH1 intron2: a novel protein isoform increases gastric cancer cell invasion and angiogenesis.
E-cadherin, a protein encoded by the CDH1 gene is the dominant epithelial cell adhesion molecule playing a crucial role in epithelial tissue polarity and structural integrity. The progression of 90% or more carcinomas is believed to be mediated by disruption of normal E-cadherin expression, subcellu...
ORGANISM(S): Homo sapiens 
2012-08-01 | E-GEOD-32540 | biostudies-arrayexpress
ProteomicsCirculating Tenascin-C/-miR-155-5p identified as promising prognostic candidates of intervertebral disc herniation
Intervertebral disc (IVD) herniation is a complex and multifactorial condition with challenging diagnosis and limited therapeutic options, highlighting the need for reliable biomarkers to improve clinical decision-making. The aim of this study was to identify circulating prognostic biomarkers of IVD...
ORGANISM(S): Rattus norvegicus (Rat) 
2026-02-02 | PXD071649 | Pride
Disc herniation Proteomics Mirna Intervertebral disc Circulating biomarkers 
ProteomicsSyndecan-4 is a maestro of gastric cancer cell invasion and communication that underscores poor survival
Gastric cancer is a dominating cause of cancer-associated mortality with limited therapeutic options. Here, we show that syndecan-4 (SDC4), a plasma membrane proteoglycan, is highly expressed in intestinal subtype gastric tumours and that this signature associates with patients’ poor survival. Furth...
ORGANISM(S): Homo sapiens (Human) 
2023-05-05 | PXD035679 | Pride
Extracellular vesicles Extracellular communication Gastric cancer Syndecan-4 Heparan sulfate proteoglycans Cancer cell invasion 
ProteomicsProteomic identification of a gastric tumor ECM signature associated with cancer progression
The extracellular matrix (ECM) plays an undisputable role in tissue homeostasis and its deregulation leads to altered mechanical and biochemical cues that impact cancer development and progression. Herein, we undertook a novel approach to address the role of gastric ECM in tumorigenesis, which remai...
ORGANISM(S): Homo sapiens (Human) 
2022-05-20 | PXD029782 | Pride
Proteomics Gastric cancer Matrisome Extracellular matrix Biomarker 
ProteomicsBiofilm matrix regulation by Candida glabrata Zap1 under acidic conditions: transcriptomic and proteomic analyses
The vaginal acidic environment potentiates the formation of Candida glabrata biofilms, leading to complicated and recurrent infections. Importantly, the regulation of biofilm matrix is known to contribute to the recalcitrant features of Candida biofilms. In this study we reveal a new matrix regulato...
ORGANISM(S): Candida glabrata (Yeast) (Torulopsis glabrata) 
2024-10-28 | PXD044153 | Pride
Candida spp. Transcriptome Zap1 targets Acidic environment Proteome Biofilm matrix 
ProteomicsA Minimally-invasive Extracellular Vesicle-based Approach for Monitoring Measurable Residual Disease in Acute Myeloid Leukemia
Measurable residual disease (MRD) in acute myeloid leukemia (AML) is monitored through detection of leukemia associated phenotypic protein markers (LAPMs) in bone marrow aspirates, hindering disease real-time monitoring. We explored peripheral blood (PB) extracellular vesicles (EVs)-based methods fo...
ORGANISM(S): Homo sapiens (Human) 
2026-06-29 | PXD071884 | Pride
Acute myeloid leukemia  measurable residual disease  liquid biopsies  extracellular vesicles 
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