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ProteomicsArabidopsis thaliana responds to colonisation of Piriformospora indica by secretion of symbiosis specific proteins
Plants interact with a wide variety of fungi in a mutualistic, parasitic or neutral way. The associations formed depend on the exchange of nutrients and signalling molecules between the partners. The latter include a diverse set of protein classes, of which some have been demonstrated to be function...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) Piriformospora sp. 
2019-01-07 | PXD009563 | Pride
Scopolin Piriformospora indica Er body Plat Secretome 
ProteomicsAnalysis of Nipah virus replication and host proteome response patterns in differentiated porcine airway epithelial cells cultured at the air-liquid interface
Respiratory tract epithelium infection is considered crucial for airborne transmission of Nipah virus (NiV). Knowledge about infection dynamics and host responses to NiV infection in respiratory tract epithelia is scarce. Various studies in non-differentiated primary respiratory tract cells or cell ...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2023-05-10 | PXD032673 | Pride
Sdgf Sdgsdf 
TranscriptomicsMetabolic and transcriptomic responses of leaves from European potato reference cultivars with differential tolerance to long-term drought
Systems responses of mature leaves from 4 reference cultivars of a larger collection of European potato cultivars (Solanum tuberosum L.) are investigated by metabolome profiling and RNA-Sequencing. The chosen reference cultivars, Milva, Alegria, Desiree, and Saturna, vary in ascending order in regar...
ORGANISM(S): Solanum tuberosum 
2016-07-06 | E-GEOD-77826 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of neuroblastoma tumors with and without MYCN amplification
Purpose: Clinical courses of neuroblastomas (NBs) range from rapid progression with fatal outcome despite intensive multimodality therapies to spontaneous regression. Amplified MYCN oncogene defines a subgroup with poor outcome. However, a substantial number of MYCN single-copy NBs exhibits an aggre...
ORGANISM(S): Homo sapiens 
2007-06-01 | E-CVDE-2 | biostudies-arrayexpress
GenomicsGenome-wide DNA methylation events in TMPRSS2:ERG fusion negative prostate cancers implicate an EZH2 dependent mechanism with miRNA-26a hypermethylation.
Prostate cancer is the second most common cancer among men worldwide. Alterations in the DNA methylation pattern can be one of the leading causes for prostate cancer formation. This study is the first high throughput sequencing study investigating genome-wide DNA methylation patterns in a large coho...
ORGANISM(S): Homo sapiens 
2012-12-06 | E-GEOD-35342 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human neuroblastoma cells with and without MYCN oncogene induction and doxorubicin treatment
Purpose: Clinical courses of neuroblastomas (NBs) range from rapid progression with fatal outcome despite intensive multimodality therapies to spontaneous regression. Amplified MYCN oncogene defines a subgroup with poor outcome. However, a substantial number of MYCN single-copy NBs exhibits an aggre...
ORGANISM(S): Homo sapiens 
2007-06-01 | E-CVDE-3 | biostudies-arrayexpress
UnknownDog Owners' Perceptions of Canine Body Composition and Effect of Standardized Education for Dog Owners on Body Condition Assessment of Their Own Dogs.
Not available
S-EPMC10386090 | biostudies-literature
Proteomics5-Nitroimidazole ethers boost anti-Helicobacter pylori activity via a dual mode of action and effectively eradicate infections in vivo
Metronidazole (Metro) represents the front line-drug against Helicobacter pylori infections, but despite its crucial role as an antibiotic, little is known about its exact mode of action (MoA). To unravel cellular protein targets, we here performed activity-based protein profiling (ABPP) with tailor...
ORGANISM(S): Helicobacter pylori 26695 
2026-04-13 | PXD051773 | Pride
Abpp Full proteome Helicobacter pylori Mode of action Nitroimidazoles Secretome Lc-ms/ms 
ProteomicsCrosstalk between pentraxin-3 and humoral pattern-recognition receptors plays an essential role in immunomodulation against Aspergillus fumigatus
The study investigated the interaction between pentraxin-3 (PTX3), a soluble pattern-recognition receptor, and the fungal pathogen Aspergillus fumigatus. The aim was to identify the ligands for PTX3 and the impact of PTX3 on the immune response. A. fumigatus spores, hyphae or cell wall components we...
ORGANISM(S): Neosartorya fumigata (Aspergillus fumigatus) 
2024-08-02 | PXD043546 | Pride
Humoral immunity Surfactant protein d Aspergillus fumigatus Pentraxin-3 C1q C3b 
ProteomicsScreening privileged alkylguanidinium motifs under host-mimicking conditions reveals a novel antibiotic with an unconventional mode of action
Screening large molecule libraries against pathogenic bacteria is often challenged by a low hit rate due to limited uptake, underrepresentation of antibiotic structural motifs and assays which do not resemble the infection conditions. To address these limitations, we here screen a library focused on...
ORGANISM(S): Staphylococcus aureus 
2024-07-17 | PXD051986 | Pride
Antibiotics Chemical proteomics Sar Moa studies Guanidinium 
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