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ProteomicsDisulfide mapping of J-chain by crosslinking MS
Here we show how J-chain (JC) outcompetes the sixth IgM subunit during assembly. We looked at the disulfide re-arrangements in JC and showed that it exists as an unstructured protein with non-native disulfides before its insertion into IgM.
ORGANISM(S): Mus musculus (Mouse) 
2024-12-04 | PXD048614 | Pride
Disulfide J-chain Crosslinking 
UnknownHow J-chain ensures the assembly of immunoglobulin IgM pentamers.
Not available
S-EPMC11729874 | biostudies-literature
UnknownIn-situ probing of the Fischer-Tropsch reaction on Co single crystal surfaces up to 1 bar.
Not available
S-EPMC11761050 | biostudies-literature
ProteomicsSmall Molecule Degraders of the Hepatitis C Virus Protease Reduce Susceptibility to Resistance Mutations
Targeted protein degradation (TPD) has emerged as a promising new drug development paradigm. We leveraged this strategy to develop a new class of small molecule antivirals that induce proteasomal degradation of viral proteins. Telaprevir, a ‘reversible-covalent’ inhibitor that binds to the hepatitis...
ORGANISM(S): Homo sapiens (Human) 
2019-07-03 | PXD014346 | Pride
Crl4 Thalidomide Hcv Protac Ubiquitin Telaprevir 
MetabolomicsMetabolic Drug Response Phenotyping in Colorectal Cancer Organoids by LC-QTOF-MS
As metabolic rewiring is crucial for cancer cell proliferation, metabolic phenotyping of patient-derived organoids is desirable to identify drug-induced changes and trace metabolic vulnerabilities of tumor subtypes. We established a novel protocol for metabolomic and lipidomic profiling of colorecta...
2021-10-12 | MTBLS2130 | MetaboLights
MetabolomicsEvidence of altered fatty acid metabolism in dogs with naturally occurring valvular heart disease and congestive heart failure

INTRODUCTION: Myxomatous mitral valve disease (MMVD) is the most common cardiac condition in adult dogs. The disease progresses over several years and affected dogs may develop congestive heart failure (HF). Research has shown that myocardial metabolism is altered in cardiac dise...

2022-03-31 | MTBLS716 | MetaboLights
MetabolomicsMetabolic phenotyping of urine from a dementia research cohort
To better understand the molecular mechanisms underpinning physiological variation in human populations, metabolic phenotyping approaches are increasingly being applied to studies involving hundreds and thousands of biofluid samples. Hyphenated ultra-performance liquid chromatography-mass spectromet...
2022-03-01 | MTBLS719 | MetaboLights
TranscriptomicsA rat RNA-Seq transcriptomic Bodymap across eleven organs and four developmental stages
The rat has been used extensively as a model for evaluating chemical toxicities and for understanding drug mechanisms. However, its transcriptome across multiple organs, or developmental stages, has not yet been reported. Here we show, as part of the SEQC consortium efforts, a comprehensive rat tran...
ORGANISM(S): Rattus norvegicus 
2014-02-14 | E-GEOD-53960 | biostudies-arrayexpress
UnknownMultiple roles of a conserved GAF domain tyrosine residue in cyanobacterial and plant phytochromes.
Not available
S-EPMC1343512 | biostudies-literature
MetabolomicsFecal microbiota transplantation plus anti-PD-1 immunotherapy in advanced melanoma: a phase I trial

Fecal microbiota transplantation (FMT) represents a potential strategy to overcome resistance to immune checkpoint inhibitors in patients with refractory melanoma; however, the role of FMT in first-line treatment settings has not been evaluated. We conducted a multicenter phase I trial combining ...

2025-02-27 | MTBLS711 | MetaboLights
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