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ProteomicshnRNP R Knock-out affects the axonal and somatic proteome
We grew neurons in microchambers to separate axons and soma in different compartments which could be independently harvested for proteomic analysis. Using this model system, we studied the effect of the knock-out of hnRNP R on the axonal and somatic proteome.
ORGANISM(S): Mus musculus (Mouse) 
2024-08-22 | PXD038368 | Pride
Hnrnp r Axon Proteome 
TranscriptomicsHepatic gene expression changes in aging and R-?-lipoic acid supplementation: Necroinflammatory phenotype, lipid synthesis regulation and circadian rhythms.
To determine the effects of age and lipoic acid supplementation on hepatic gene expression, we fed young (3 months) and old (24 months) male Fischer 344 rats a diet with or without 0.2% (w/w) R-?-lipoic acid (LA) for two weeks. Total RNA isolated from liver tissue was analyzed by Affymetrix microarr...
ORGANISM(S): Rattus norvegicus 
2011-03-03 | E-GEOD-27625 | biostudies-arrayexpress
ProteomicshnRNP R promotes O-GlcNAcylation of eIF4G to facilitate axonal protein synthesis
Motoneurons critically depend on precise spatial and temporal control of translation for axon growth and the establishment and maintenance of neuromuscular connections. While defects in local translation have been implicated in the pathogenesis of motoneuron disorders, little is known about mechanis...
ORGANISM(S): Mus musculus (Mouse) 
2024-08-22 | PXD052115 | Pride
Rl2 Axonal translation Ogt Interactome Motoneuron 
UnknownN-Heterocyclic Carbene Coinage Metal Complexes of the Germanium-Rich Metalloid Clusters [Ge₉R₃]- and [Ge₉RI₂]²- with R = Si(iPr)₃ and RI = Si(TMS)₃.
Not available
S-EPMC6152075 | biostudies-literature
MetabolomicsProMetIS, deep phenotyping of mouse models by combined proteomics and metabolomics analysis

Genes are pleiotropic and getting a better knowledge of their function requires a comprehensive characterization of their mutants. Here, we generated multi-level data combining phenomic, proteomic and metabolomic acquisitions from plasma and liver tissues of two C57BL/6 N mouse models lacking the...

2021-09-01 | MTBLS1903 | MetaboLights
UnknownA Primer to (Cross-Cultural) Multi-Group Invariance Testing Possibilities in R.
Not available
S-EPMC6657455 | biostudies-literature
MetabolomicsUntargeted Metabolomics for Integrative Taxonomy: Metabolomics, DNA Marker-Based Sequencing, and Phenotype Bioimaging

Integrative taxonomy is a fundamental part of biodiversity and combines traditional morphology with additional methods such as DNA sequencing or biochemistry. Here, we aim to establish untargeted metabolomics for use in chemotaxonomy. We used three thallose liverwort species Riccia glauca

2026-01-30 | MTBLS4668 | MetaboLights
ProteomicsCompromised transcription-mRNA export factor THOC2 causes R-loop accumulation, DNA damage and adverse neurodevelopment
We implicated the X-chromosome THOC2 gene, which encodes largest subunit of the highly-conserved TREX (Transcription-Export) complex, in a clinically variable neurodevelopmental disorder with intellectual disability as the core phenotype. To study how compromised function of this essential eukaryoti...
ORGANISM(S): Mus musculus (Mouse) 
2024-02-12 | PXD040358 | Pride
Brain Mice Thoc2 Proteomics 
MetabolomicsEvidence for quorum sensing and differential metabolite production by Ruegeria pomeroyi in response to DMSP
Microbial alteration and remineralization of organic matter in the ocean play essential roles in the carbon cycle. The impact of individual compounds as either growth substrates or infochemicals is still poorly constrained in models, particularly for organisms with relatively versatile genomes. Here...
2015-01-29 | MTBLS157 | MetaboLights
UnknownMETTL3 drives telomere targeting of TERRA lncRNA through m6A-dependent R-loop formation: a therapeutic target for ALT-positive neuroblastoma.
Not available
S-EPMC10954483 | biostudies-literature
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