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ProteomicsThermal proteome profilling of Ergothionine treated-cells reveals its binding to cystathionine-gamma-lyase (CSE)
Ergothioneine (ET), a dietary thione/thiol, is receiving growing attention for its possible benefits in healthy aging and metabolic resilience. Our study investigates ET's effects on healthspan in aged animals, revealing extension of lifespan and enhanced mobility in Caenorhabditis elegans, accompan...
ORGANISM(S): Mus musculus (Mouse) 
2025-01-20 | PXD051609 | Pride
Ergothioneine Healthspan Persulfidation Hydrogen sulfide Nad 
TranscriptomicsTranscription profiling of hyperthermophilic crenarchaeum Thermoproteus tenax to compare autotrophic growth on CO2/H2 versus heterotrophic growth on glucose using a focussed central carbohydrate metabolism DNA microarray
In order to unravel the role of regulation on transcript level in the central carbohydrate metabolism (CCM) of Thermoproteus tenax (glycolytic/gluconeogenic carbon switch), the focused DNA microarray was constructed by using ORFs supposed to be involved in the CCM pathways. Transcriptional profiling...
ORGANISM(S): Thermoproteus tenax 
2008-02-05 | E-MEXP-1376 | biostudies-arrayexpress
ProteomicsIdentification of protein-trichloroethene interactions during organohalide respiration revealed by thermal proteome profiling
The organohalide-respiring Sulfurospirillum multivorans uses chlorinated ethenes as electron acceptors for growth under anoxic conditions. However, little is known about the interaction of these substrates with proteins. Here, we apply thermal proteome profiling (TPP) to analyze enzyme-trichloroethe...
ORGANISM(S): Sulfurospirillum multivorans DSM 12446 
2018-06-06 | PXD009308 | Pride
Thermal proteome profiling (tpp)  interaction proteome  organohalide respiration  reductive dehalogenases  sulfurospirillum multivorans  dehalococcoides mccartyi  quantitative proteomics 
UnknownGender- and sex-sensitive psychopharmacotherapy of alcohol use disorder: a systematic review and meta-analysis protocol.
Not available
S-EPMC12682176 | biostudies-literature
UnknownAquaporin tetramer composition modifies the function of tobacco aquaporins.
Not available
S-EPMC2951199 | biostudies-literature
TranscriptomicsTelomerase is a prognostic marker of poor outcome and a therapeutic target in neuroblastoma
The aim of this study is to determine the clinical relevance of telomerase activation versus ALT as biomarkers in pre-treatment neuroblastoma, and to assess the potential value of telomerase as a therapeutic target. Therefore, the genomic status of TERT and MYCN was assessed in 457 pretreatment neur...
ORGANISM(S): Homo sapiens 
2019-09-16 | E-MTAB-8248 | biostudies-arrayexpress
GenomicsDAC University Hospital Cologne
Data Access Committee EGAC00001000361
EGAC00001000361 | EGA
ProteomicsProteomic analyisis of cultured human podocytes stimulated with TNFa - supernatant
TNFa stimulated human cultured podocytes compared with unstimulated (vehicle control (VC)) podocytes. Incubation of podocytes with high concentrations of TNF alpha led to an overexpression of ICAM1 in particular. We studied this system as a comparator for organoids also stimulated with the same conc...
ORGANISM(S): Homo sapiens (Human) 
2023-05-19 | PXD032130 | Pride
Inflammation Podocytes Inflammatory response Cytokines 
ProteomicsProteomic analyisis of cultured human podocytes stimulated with TNFa - cell pellet
TNFa stimulated human cultured podocytes compared with unstimulated (vehicle control (VC)) podocytes. Incubation of podocytes with high concentrations of TNF alpha led to an overexpression of ICAM1 in particular. We studied this system as a comparator for organoids also stimulated with the same conc...
ORGANISM(S): Homo sapiens (Human) 
2023-05-19 | PXD032107 | Pride
Inflammation Podocytes Inflammatory response Cytokines 
ProteomicsProteome analysis of kidney organoid cells during TNFa stimulation
Kidney organoids are a valuable and innovative model to understand genetic diseases, kidney development and transcriptomic dynamics. However, their proteome has not been analyzed so far. Here, we analyzed the organoid proteome after treatment of organoids with 5ng/mL TNFalpha for 24h and 48h compare...
ORGANISM(S): Homo sapiens (Human) 
2023-05-12 | PXD029718 | Pride
Tnfalpha Cytokine Shotgun lc ms/ms Human kidney organoids Tnfa 
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