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ProteomicsDevelopmental mRNA clearance by PIWI-bound endo-siRNAs in Paramecium
The clearance of untranslated mRNAs by Argonaute proteins is essential for embryonic development in metazoans. However, it is currently unknown whether a similar process exists in unicellular eukaryotes. The ciliate Paramecium tetraurelia harbors a vast array of Argonaute proteins of the Piwi-clade ...
ORGANISM(S): Paramecium tetraurelia 
2023-05-10 | PXD038984 | Pride
Paramecium tetraurelia Piwi Mrna clearance Untranslated mrna Total protein < 25kda Sirnas 
ProteomicsmtTF1: A Novel Factor Involved in Mitochondrial Gene Expression in Trypanosoma brucei
Identification of a novel mitochondrial transcription factor in Trypanosoma brucei.
ORGANISM(S): Trypanosoma brucei 
2026-10-05 | PXD079303 | Pride
Trypanosoma brucei Mitochondrial transcription Mitochondria Mitochondrial rna polymerase 
ProteomicssAPP a neuroprotective protein in the brain has widespread effects on the proteome of human cortical neurons related to memory mechanisms.
Human glutamatergic neurons in culture were exposed to 1 nM secreted amyloid precursor protein alpha over a time course (0, 2, 6 and 24 h) and changes in the proteome were identified with SWATH-MS.
ORGANISM(S): Homo sapiens (Human) 
2022-04-03 | PXD031704 | Pride
App Alzheimer’s disease Proteome. Sappa Human neuron 
UnknownAblation of endothelial VEGFR1 improves metabolic dysfunction by inducing adipose tissue browning.
Not available
S-EPMC5789413 | biostudies-literature
GenomicsActivation and repression by oncogenic Myc shapes tumour-specific gene expression profiles
In mammalian cells, the Myc oncoprotein binds to thousands of promoters. During mitogenic stimulation of primary lymphocytes, Myc promotes an increase in expression of virtually all genes. In contrast, Myc-driven tumour cells differ from normal cells in expression of specific sets of up- and downreg...
ORGANISM(S): Homo sapiens 
2014-07-10 | E-GEOD-44672 | biostudies-arrayexpress
UnknownUnraveling the Genetics of Shared Clinical and Serological Manifestations in Patients With Systemic Inflammatory Autoimmune Diseases.
Not available
S-EPMC11782108 | biostudies-literature
TranscriptomicsGene expression in striatums of Foxp2-hum, Foxp2-ko and wild-type mice
It has been proposed that two amino acid substitutions in the transcription factor FOXP2 have been positively selected during human evolution due to effects on aspects of speech and language. Here, we introduce these substitutions into the endogenous Foxp2 gene.of mice. Although these mice are gener...
ORGANISM(S): Mus musculus 
2010-05-22 | E-GEOD-13588 | biostudies-arrayexpress
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