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ProteomicsCodY regulates the activity of the virulence quorum sensor PlcR
In Gram-positive bacteria, cell-cell communication mainly relies on cytoplasmic sensors of the RNPP family. Activity of these regulators depends on their binding to secreted signaling peptides that are imported into the cell. These quorum sensing regulators control important biological functions in ...
ORGANISM(S): Bacillus thuringiensis Bt407 
2015-12-17 | PXD003311 | Pride
Opp Bacillus Cody Mass spectrometry Plcr Signaling peptide Quorum-sensing Virulence regulon Shot gun Regulation 
ProteomicsDifferential contributions of CodY, SigB and the hibernation promoting factor HPF to interactions of Staphylococcus aureus USA300 with human lung epithelial cells explained by proteome analysis
The Gram-positive bacterium Staphylococcus aureus is a leading cause of severe pneumonia. Therefore, we recently investigated the fate of S. aureus upon internalization by human lung epithelial cells. This uncovered three major adaptive responses of the bacteria, involving the SigB and CodY regulons...
ORGANISM(S): Staphylococcus aureus 
2024-09-11 | PXD044962 | Pride
Epithel cells Usa300 Hibernation promoting factor Staphylococcus aureus 
ProteomicsPrenylcysteine oxidase 1 like protein is required for neutrophil bactericidal activities
The bactericidal function of neutrophils are dependent on myriad intrinsic and extrinsic stimuli. Using systems immunology approaches we identified microbiome- and infection-induced changes in neutrophils. We focused on investigating the Prenylcysteine oxidase 1 like (Pcyox1l) protein function. Muri...
ORGANISM(S): Mus musculus (Mouse) 
2023-04-14 | PXD031115 | Pride
Neutrophil Prenylation Pcyox1l 
ProteomicsAnother layer of complexity in Staphylococcus aureus methionine biosynthesis control: Unusual RNase III-driven T-box riboswitch cleavage determines met operon mRNA stability and decay
In Staphylococcus aureus, de novo methionine biosynthesis is regulated by a unique hierarchical pathway involving stringent-response controlled CodY repression in combination with a T-box riboswitch and RNA decay. The T-box riboswitch residing in the 5' untranslated region (met leader RNA) of the S....
ORGANISM(S): Staphylococcus aureus (strain Newman) 
2021-08-10 | PXD020619 | Pride
Methionine biosynthesis Staphylococcus aureus Rna decay T-box riboswitch 
ProteomicsAnother layer of complexity in Staphylococcus aureus methionine biosynthesis control: Unusual RNase III-driven T-box riboswitch cleavage determines met operon mRNA stability and decay
In Staphylococcus aureus, de novo methionine biosynthesis is regulated by a unique hierarchical pathway involving stringent-response controlled CodY repression in combination with a T-box riboswitch and RNA decay. The T-box riboswitch residing in the 5' untranslated region (met leader RNA) of the S....
ORGANISM(S): Staphylococcus aureus (strain Newman) 
2021-02-18 | PXD022677 | Pride
Methionine biosynthesis Staphylococcus aureus Rna decay T-box riboswitch 
UnknownThe Shape of the Glucose Response Curve During an Oral Glucose Tolerance Test: Forerunner of Heightened Glycemic Failure Rates and Accelerated Decline in β-Cell Function in TODAY.
Not available
S-EPMC6300703 | biostudies-literature
UnknownLipid Profiles, Inflammatory Markers, and Insulin Therapy in Youth with Type 2 Diabetes.
Not available
S-EPMC6436626 | biostudies-literature
UnknownEnhanced contact investigations for nine early travel-related cases of SARS-CoV-2 in the United States.
Not available
S-EPMC7467265 | biostudies-literature
UnknownLongitudinal Correlates of Health Risk Behaviors in Children and Adolescents with Type 2 Diabetes.
Not available
S-EPMC4414713 | biostudies-literature
UnknownPredictors of response to insulin therapy in youth with poorly-controlled type 2 diabetes in the TODAY trial.
Not available
S-EPMC6953481 | biostudies-literature
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