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ProteomicsBiomarkers of favorable immune capacity in growth hormone receptor knockout pig model
Laron Syndrome (LS) is a rare hereditary disease in humans caused by a mutation in the growth hormone receptor gene which leads to high levels of circulating GH [1]. The disease is characterized by short statue, obesity, transient hypoglycemia during youth and low incidences of cancer and diabetes [...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2023-07-20 | PXD038772 | Pride
Quantitative label-free lc-ms/ms  laron syndrome  ghr-ko  porcine model  immune function 
MetabolomicsMetabolomics-Driven Discovery of an Introduced Species and Two Malaysian Piper betle L. Variants
The differences in pungency of 'sirih' imply the probable occurrence of several variants of Piper betle L. in Malaysia. However, the metabolite profiles underlying the pungency of the different variants remain a subject of further research. The differences in metabolite profiles of selected M...
2022-03-21 | MTBLS2585 | MetaboLights
ProteomicsThrombo-Inflammation in Preeclampsia and Pregnancy Induced Hypertension: Proteomics And Metabolomics Profiling of Platelets and Plasma Mediators
Background: Platelets may be pivotal mediators of the thrombo-haemorrhagic complications of preeclampsia (PE), linking inflammation and thrombosis with endothelial and vascular dysfunction. While gestational hypertension (GH) falls within the spectrum of hypertensive complications of pregnancy and i...
ORGANISM(S): Homo sapiens (Human) 
2022-03-16 | PXD031278 | Pride
Metabolomics String bg Preeclampsia Pregnancy Gestational hypertension Proteomics Pathway analysis Lrrc27/42 
ProteomicsThe proteasome biogenesis regulator Rpn4 cooperates with the unfolded protein response to promote ER stress resistance
Misfolded proteins in the endoplasmic reticulum (ER) activate the unfolded protein response (UPR), which enhances protein folding to restore homeostasis. Additional pathways respond to ER stress, but how they help counteract protein misfolding is incompletely understood. Here, we develop a titratabl...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2019-03-13 | PXD012867 | Pride
Human cells Autophagy Dynamic organellar maps Ap-4 Vesicles 
TranscriptomicsThe effects of UVB and the organic osmolyte betaine on rat epidermal keratinocytes in an organotypic culture system
Betaine (trimethylglycine) is a non-toxic, highly water-soluble organic osmolyte widely used in skin care due to its assumed moisturizing and protective properties, but only few studies have addressed its specific effects in skin. Here, the cellular and molecular targets of betaine were analyzed by ...
ORGANISM(S): Rattus norvegicus 
2015-10-26 | E-GEOD-63004 | biostudies-arrayexpress
MetabolomicsLung Lipidomic Alterations in Beagle Dogs Infected with Toxocara canis

Toxocariasis, mainly caused by Toxocara canis, and to a lesser extent, Toxocara cati, is a neglected parasitic zoonosis. The mechanisms that underlie the changes in lipid metabolism of T. canis infection in Beagle dogs' lungs remain unclear. Lipidomics is a rapidly emer...

2023-08-21 | MTBLS5583 | MetaboLights
ProteomicsImmunometabolism in resolving atherosclerosis guides the development of nanometabolite therapy
A 6-month in vivo study will be carried out at Case Western Reserve University (CWRU) using an ApoE-/- mouse model of atherosclerosis (obtained from The Jackson Laboratory), which will be treated as follows: Control: Mice fed a chow diet (control) (n=12) Progression: Mice fed a high-fat diet with ch...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-06 | PXD041137 | Pride
Organoids Stable isotope metabolomics Mouse Aorta 
MetabolomicsUntargeted lipidomic profiling of grape highlights the importance of modified lipid species beyond the traditional compound classes

The aim of this paper is to provide a detailed characterisation of grape lipidome. To achieve this objective, it starts by describing a pipeline implemented in R software to allow the semi-automatic annotation of the detected lipid species. It also provides an extensive description of the differe...

2023-01-02 | MTBLS5261 | MetaboLights
MetabolomicsIntegrated genomic and metabolomic profiling of ISC1, an emerging Leishmania donovani population in the Indian subcontinent

Leishmania donovani is the responsible agent for visceral leishmaniasis (VL) in the Indian subcontinent (ISC). The disease is lethal without treatment and causes 0.2 to 0.4 million cases each year. Recently, reports of VL in Nepalese hilly districts have increased as well as VL cases cau...

2022-09-15 | MTBLS1606 | MetaboLights
ProteomicsEndothelins positively influences the proliferation vs. migration balance of IDH1-mutant glioma cells and promotes proneural to mesenchymal transition
Adult diffuse gliomas are the deadliest brain tumours including IDH-wildtype glioblastomas of worst prognosis and diffuse low grade IDH-mutant astrocytomas and oligodendrogliomas. These glial tumours display distinct tumoral cell population defeating current therapies. Our group has previously unvei...
ORGANISM(S): Homo sapiens (Human) 
2026-03-11 | PXD065902 | Pride
Human Lgg275 a idh-mutant low grade astrocytomas patient-derived cell line Tmt-ms/ms 
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