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ProteomicsAmphora coffeaeformis adhesive trail proteomics
Throughout all kingdoms of life, a large number of adhesive biomolecules have evolved to allow organisms to adhere to surfaces underwater. Proteins play an important role in the adhesion of numerous marine invertebrates (e.g. mussels, sea stars, sea urchins) whereas much less is known about the biol...
ORGANISM(S): Amphora coffeiformis 
2021-09-08 | PXD013773 | Pride
Adhesive Diatom 
MetabolomicsMetabolic Drug Response Phenotyping in Colorectal Cancer Organoids by LC-QTOF-MS
As metabolic rewiring is crucial for cancer cell proliferation, metabolic phenotyping of patient-derived organoids is desirable to identify drug-induced changes and trace metabolic vulnerabilities of tumor subtypes. We established a novel protocol for metabolomic and lipidomic profiling of colorecta...
2021-10-12 | MTBLS2130 | MetaboLights
ProteomicsCraspedostauros australis frustule associated components analysis
The biomolecular composition of diatom underwater adhesives remains unknown as does the precise mechanism by which the secretion of adhesive material from the raphe slit is coupled to an intracellular motor that provides the force for cell motility. In this study we have characterized the previously...
ORGANISM(S): Craspedostauros australis 
2023-01-09 | PXD026968 | Pride
Motility Frustule assopciated protein Adhesion Diatom 
TranscriptomicsRNA-Seq of conventional and regulatory CD4+ T cells of healthy human donors
Transcriptional profiles of conventional and regulatory CD4+ T cells were compared in healthy individuals (caucasian males).
ORGANISM(S): Homo sapiens 
2020-03-04 | E-MTAB-8819 | biostudies-arrayexpress
MetabolomicsLarge neutral amino acid levels tune perinatal neuronal excitability and survival
Surprisingly little is known about the critical metabolic changes that neural cells have to undergo during development and how even mild, temporary shifts in this program can influence brain circuitries and behavior. Inspired by the discovery that mutations in SLC7A5, a transporter of metabolically-...
2023-03-28 | MTBLS6578 | MetaboLights
TranscriptomicsTranscription profiling by array of lymphoblastic cells, fat and skin from twins
Gene expression was quantified in LCL, skin and fat derived from a subset of Twins UK (N=156 LCL, N=160 skin, N=166 fat) using Illuminas whole genome expression array (HumanHT-12 version 3). Cis eQTL analysis was performed in each tissue, following by multiple analyses assessing the tissue-specifici...
ORGANISM(S): Homo sapiens 
2011-02-03 | E-MTAB-522 | biostudies-arrayexpress
ProteomicsProteomics of Cycloclasticus endosymbiont of deep-sea mussel Bathymodiolus heckerae from Campeche Knolls, southern Gulf of Mexico
Bathymodiolin mussels are a group of bivalves associated with deep-sea reducing habitats, such as hydrothermal vents and cold seeps. These mussels usually engage in an obligatory symbiosis with sulfur and/or methane oxidizing Gammaproteobacteria. In addition to these bacteria, Bathymodiolus heckerae...
ORGANISM(S): Bacteria 
2016-12-05 | PXD005351 | Pride
Cycloclasticus 1d-lc Metaproteome Chemosynthetic symbiosis Metaproteomics 
MetabolomicsThe impact of nutritional supplementation on sweat metabolomic content
Sweat is emerging as a prominent biosource for real-time human performance monitoring applications. Although promising, sources of variability must be identified to truly utilize sweat for biomarker applications. In this proof-of-concept study, a targeted metabolomics method was applied to sweat col...
2021-03-15 | MTBLS2427 | MetaboLights
ProteomicsIgM hyposialylation drives podocyte injury in pediatric and young adult patients with podocytopathies
Altered immunoglobulin glycosylation has been implicated in antibody-mediated podocytopathies, yet the functional impact of IgM sialylation remains unclear. Previous evidence suggested that circulating cationic or hyposialylated IgM may contribute to podocyte injury in idiopathic nephrotic syndrome ...
ORGANISM(S): Homo sapiens (Human) 
2026-06-29 | PXD070406 | Pride
Immunoglobulin m glycosylation Hyposialylation Sialidase Podocyte injury Podocytopathies 
TranscriptomicsSost and its paralog Sostdc1 coordinate digit number in a Gli3-dependent manner
WNT signaling is critical in most aspects of skeletal development and homeostasis, and antagonists of WNT signaling are emergning as key regulatory proteins with great promise as therapeutic agents for bone disorders. Until recently Sost and its paralog Sostdc1 have been described as growth factors ...
ORGANISM(S): Mus musculus 
2013-08-17 | E-GEOD-44325 | biostudies-arrayexpress
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