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TranscriptomicsTranscription profiling of chicken with experimentally induced myopia
One-day old white Leghorn chicks were housed in brooders with a 12 hr light:dark cycle, using General Electric chroma 50 fluorescent lighting with irradiance of approximately 50μW/cm2 at chick eye level. They received Purina Chick Chow food and water ad libitum. At one week of age and at the onset ...
ORGANISM(S): Gallus gallus 
2008-11-08 | E-GEOD-6543 | biostudies-arrayexpress
ProteomicsProteomic and phosphoproteomic study in the retina, choroid, and sclera of guinea pigs with form-deprivation myopia
Myopia is a growing global public health concern. Recent studies have revealed that the regulation of eye growth occurs via a complex signaling cascade, which originates in the retina and across the choroid to the sclera. Identifying key proteins and specific biological processes in the retina, chor...
ORGANISM(S): Cavia porcellus (Guinea pig) 
2025-11-17 | PXD067757 | Pride
Retina Choroid Form-deprivation myopia Sclera Proteomics and phosphoproteomics 
ProteomicsProteomic and phosphoproteomic study in the retina, choroid, and sclera of guinea pigs with form-deprivation myopia
Myopia is a growing global public health concern. Recent studies have revealed that the regulation of eye growth occurs via a complex signaling cascade, which originates in the retina and across the choroid to the sclera. Identifying key proteins and specific biological processes in the retina, chor...
ORGANISM(S): Cavia porcellus (Guinea pig) 
2025-11-17 | PXD067756 | Pride
Retina Choroid Form-deprivation myopia Sclera Proteomics and phosphoproteomics 
ProteomicsProteomic and phosphoproteomic study in the retina, choroid, and sclera of guinea pigs with form-deprivation myopia
Myopia is a growing global public health concern. Recent studies have revealed that the regulation of eye growth occurs via a complex signaling cascade, which originates in the retina and across the choroid to the sclera. Identifying key proteins and specific biological processes in the retina, chor...
ORGANISM(S): Cavia porcellus (Guinea pig) 
2025-11-17 | PXD067446 | Pride
Retina Choroid Form-deprivation myopia Sclera Proteomics and phosphoproteomics 
ProteomicsLactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia
Myopia has become the major cause of visual impairment worldwide. Although the pathogenesis of myopia remains controversial, proteomics studies suggest that dysregulation of retinal metabolism is potentially involved in the pathology of myopia. Lysine lactylation of proteins plays a key role in regu...
ORGANISM(S): Cavia porcellus (Guinea pig) 
2024-10-17 | PXD046495 | Pride
Lysine lactylation Form-deprivation myopia Lactate Aerobic glycolysis Retina 
TranscriptomicsForm deprivation modulates retinal neurogenesis in primate experimental myopia
Juvenile primates develop myopia when their visual experience is degraded by lid fusion. In response to the abnormal visual input, retinal neural networks cause an excessive growth of the postequatorial segment of the eye, but the mechanism underlying this axial elongation is unknown. By combining a...
ORGANISM(S): Macaca mulatta 
2010-07-01 | E-GEOD-3300 | biostudies-arrayexpress
ProteomicsProteomic and phosphoproteomic study in the retina, choroid, and sclera of guinea pigs with form-deprivation myopia
Myopia is a growing global public health concern. The retinal–choroid–sclera (RCS) signalling cascade is crucial in regulating eye growth and is influenced by visually induced signalling. Understanding the molecular mechanisms underlying this cascade is vital to identify therapeutic targets for myop...
ORGANISM(S): Mus musculus (Mouse) 
2025-11-17 | PXD052167 | Pride
Phosphoproteomic Proteomic Form-deprivation myopia (fdm)  retina-choroid-sclera (rcs) 
ProteomicsWidespread Involvement of Acetylation in the Retinal Metabolism of Form-Deprivation Myopia in Guinea Pigs
Myopia has become the major cause of visual impairment worldwide. Although the pathogenesis of myopia remains controversial, proteomics studies suggest that dysregulation of retinal metabolism is potentially involved in the pathology of myopia. Lysine acetylation of proteins plays a key role in regu...
ORGANISM(S): Cavia porcellus (Guinea pig) 
2023-07-12 | PXD043196 | Pride
Form-deprivation myopia  retina  lysine acetylation  glycolysis 
ProteomicsProteomic study of the retina of guinea pigs with form-deprivation myopia
Myopia has become the major cause of visual impairment worldwide. However, its retina-related pathogenesis remains unclear. In recent years, proteomics has become a high-throughput tool to explain biological mechanisms. In this study, we examined the retinas of guinea pigs with form deprivation myop...
ORGANISM(S): Cavia porcellus (Guinea pig) 
2023-07-12 | PXD043226 | Pride
Guinea pig Proteome Retina 
GenomicsEvaluation of MicroRNA Expression Profiles for Form-Deprivation Myopia in Mouse
The study aim was to determine microRNA (miRNA) expression profiles of ocular tissues in form-deprivation induced myopia (FDM) mice. Form-deprivation myopia was induced in C57BL/6Jmice over the right eye; the contralateral left eyes were used as controls. Whole genome microRNA expression profiles in...
ORGANISM(S): Mus musculus 
2014-12-31 | GSE58124 | GEO
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